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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
neuroscience
Up-regulation of TLR-4 in the brain after ischemic kidney-induced encephalopathy in the rat
CNS and Neurological Disorders - Drug Targets, Volume 12, No. 5, Year 2013
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Description
Ischemic acute kidney injury (AKI) is usually accompanied by neuroinflammation-induced encephalopathy. However, the specific mechanism remains unclear. Toll-like receptors (TLR), specifically TLR-4 has been linked to ischemic reperfusion injury in different organs like kidney, brain and liver. Here, we induced an ischemic reperfusion kidney injury in Sprague Dawley rats. All animals were evaluated using behavioral tests which revealed locomotor activity and motor disturbances in the AKI group. The brains were then examined by immunostaining with ionized calcium binding adaptor molecule 1 (microglial marker) and TLR-4 antibodies. The histological analysis revealed significant up-regulation of TLR-4 in the hippocampus and striatum in the AKI group. These data demonstrate for the first time, the triggering effect of TLR-4 on AKI-induced neuroinflammation in the brain that may lead to AKI-induced encephalopathy. This would also generate a novel hypothesis that using TLR blockers may have a role in preventing AKI effects on the brain. © 2013 Bentham Science Publishers.
Authors & Co-Authors
Salama, Mohamed M.
Egypt, Mansoura
Faculty of Medicine
Farrag, Sally Mohamed
Egypt, Mansoura
Faculty of Medicine
Abulasrar, Sarah Abulfath
Egypt, Mansoura
Faculty of Medicine
Amin, Maha Mohamed
Egypt, Mansoura
Mansoura University
Abdel-Aziz, Azza A.
Egypt, Mansoura
Mansoura University
Sheashaa, Hussein Atia
Egypt, Mansoura
Faculty of Medicine
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Sobh, Mohamed Abdel Kader
Egypt, Mansoura
Faculty of Medicine
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Arias-Carrion, Oscar
Mexico, Mexico
Hospital General Dr. Manuel Gea González
Statistics
Citations: 24
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.2174/1871527311312050006
ISSN:
18715273
e-ISSN:
19963181
Research Areas
Violence And Injury