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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Factors associated with the duration of moderate-to-severe diarrhea among children in Rural Western Kenya enrolled in the global enteric multicenter study, 2008-2012
American Journal of Tropical Medicine and Hygiene, Volume 97, No. 1, Year 2017
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Description
Diarrheal disease is a leading cause of death among young children worldwide. As rates of acute diarrhea (AD; 1-6 days duration) have decreased, persistent diarrhea (PD; > 14 days duration) accounts for a greater proportion of the diarrheal disease burden.Wedescribe factors associated with the duration of moderate-to-severe diarrhea in Kenyan children < 5 years old enrolled in the Global Enteric Multicenter Study. We found 587 (58%) children experienced AD, 360 (35%) had prolonged acute diarrhea (ProAD; 7-13 days duration), and 73 (7%) had PD.Weconstructed a Cox proportional hazards model to identify factors associated with diarrheal duration. Risk factors independently associated with longer diarrheal duration included infection with Cryptosporidium (hazard ratio [HR]: 0.868, P = 0.035), using an unimproved drinking water source (HR: 0.87, P = 0.035), and being stunted at enrollment (HR: 0.026, P < 0.0001). Diarrheal illness of extended duration appears to be multifactorial; given its association with adverse health and development outcomes, effective strategies should be implemented to reduce the duration and severity of diarrheal illness. Effective treatments for Cryptosporidium should be identified, interventions to improve drinking water are imperative, and nutrition should be improved through exclusive breastfeeding in infants ≤ 6 months and appropriate continued feeding practices for ill children. © 2017 by The American Society of Tropical Medicine and Hygiene.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC5508904/bin/tpmd160898.SD1.pdf
Authors & Co-Authors
Schilling, Katharine A.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Omore, Richard
United States, Atlanta
Centers for Disease Control and Prevention
Kenya, Nairobi
Kenya Medical Research Institute
Derado, Gordana
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Ayers, Tracy L.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Ochieng, John Benjamin
United States, Atlanta
Centers for Disease Control and Prevention
Kenya, Nairobi
Kenya Medical Research Institute
Farag, Tamer H.
United States, Baltimore
University of Maryland School of Medicine
Nasrin, Dilruba
United States, Baltimore
University of Maryland School of Medicine
Panchalingam, Sandra
United States, Baltimore
University of Maryland School of Medicine
Nataro, James Paul
United States, Baltimore
University of Maryland School of Medicine
United States, Charlottesville
University of Virginia School of Medicine
Kotloff, Karen L.
United States, Baltimore
University of Maryland School of Medicine
Levin, Myron J.
United States, Baltimore
University of Maryland School of Medicine
Oundo, Joseph Wang Ang’a A.
United States, Atlanta
Centers for Disease Control and Prevention
Parsons, Michele B.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Bopp, Cheryl A.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Laserson, Kayla F.
United States, Atlanta
Centers for Disease Control and Prevention
Stauber, Christine Elizabeth
United States, Atlanta
Georgia State University
Rothenberg, Richard B.
United States, Atlanta
Georgia State University
Breiman, Robert F.
United States, Atlanta
Centers for Disease Control and Prevention
United States, Atlanta
Emory University
O'Reilly, Ciara E.
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Mintz, Eric Daniel
United States, Atlanta
National Center for Emerging and Zoonotic Infectious Diseases
Statistics
Citations: 20
Authors: 20
Affiliations: 7
Identifiers
Doi:
10.4269/ajtmh.16-0898
ISSN:
00029637
Research Areas
Environmental
Food Security
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Kenya