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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Microdistribution of the resistance of malaria vectors to deltamethrin in the region of Plateau (southeastern Benin) in preparation for an assessment of the impact of resistance on the effectiveness of Long Lasting Insecticidal Nets (LLINs)
BMC Infectious Diseases, Volume 14, No. 1, Article 103, Year 2014
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Description
Background: This study aims to research two areas, one with a resistant and the other with a susceptible profile of An. gambiae to deltamethrin in the region of Plateau (southern Benin). In each area, eight localities were sought. Both areas were needed for the assessment of the impact of malaria vector resistance to pyrethroids on the effectiveness of Long Lasting Insecticidal Nets (LLINs). The susceptible area of An. gambiae to deltamethrin was used as a control.Methods: In total, 119 localities in the region of Plateau were screened by sampling An. gambiae s.l larvae. Female mosquitoes resulting from these larvae were exposed to 0.05% deltamethrin following WHO standards. PCR was used to identify species and molecular forms of the dead and alive mosquitoes. Finally, we identified kdr mutations (1014 F and1014S) using the HOLA technique.Results: Fifty-six out of 119 prospected localities tested positive for Anopheles gambae s.l breeding sites. The results showed that An. gambiae was resistant to deltamethrin in 39 localities and susceptible in only 2 localities; resistance to deltamethrin was suspected in 15 localities. The HOLA technique confirmed the presence of kdr 1014 F mutation and the absence of kdr 1014S mutation. The kdr 1014 F mutation was found in both M and S molecular forms at relatively high frequencies therefore confirming the susceptibility tests.Conclusion: We were unable to identify the eight susceptible areas due to the overall resistance of An. gambiae to deltamethrin in the region of Plateau. To implement the study, we kept two areas, one with high resistance (R+++) and the other with low resistance (R+) of An. gambiae to deltamethrin. © 2014 Sovi et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Sovi, Arthur
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Djègbé, Innocent
Benin, Cotonou
International Institute of Tropical Agriculture Contonou
Soumanou, Lawal
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Tokponnon, Filémon Tatchémè
Benin
Programme Nationale de Lutte Contre le Paludisme
Gnanguénon, Virgile
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Azondekon, Roseric
United States, Amherst
University of Massachusetts Amherst
Oké-Agbo, Frédéric
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Okê-Sopoh, Mariam
Benin
Programme Nationale de Lutte Contre le Paludisme
Adéchoubou, Alioun
Benin
Programme Nationale de Lutte Contre le Paludisme
Massougbodji, Achille
Benin, Cotonou
University of Abomey-calavi
Corbel, Vincent
France, Montpellier
Maladies Infectieuses et Vecteurs : Écologie, Génétique, Évolution et Contrôle
Thailand, Bangkok
Kasetsart University
Akogbéto, Martin Codjo
Benin, Cotonou
Centre de Recherche Entomologique de Cotonou
Statistics
Citations: 20
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1186/1471-2334-14-103
e-ISSN:
14712334
Research Areas
Cancer
Infectious Diseases
Study Locations
Benin
Participants Gender
Female