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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA
European Journal of Immunology, Volume 43, No. 10, Year 2013
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Description
Cerebral malaria is a severe complication of Plasmodium falciparum infection. Although T-cell activation and type II IFN-γ are required for Plasmodium berghei ANKA (PbA)-induced murine experimental cerebral malaria (ECM), the role of type I IFN-α/β in ECM development remains unclear. Here, we address the role of the IFN-α/β pathway in ECM devel-opment in response to hepatic or blood-stage PbA infection, using mice deficient for types I or II IFN receptors. While IFN-γR1-/- mice were fully resistant, IFNAR1-/- mice showed delayed and partial protection to ECM after PbA infection. ECM resistance in IFN-γR1-/- mice correlated with unaltered cerebral microcirculation and absence of ischemia, while WT and IFNAR1-/- mice developed distinct microvascular pathologies. ECM resistance appeared to be independent of parasitemia. Instead, key mediators of ECM were attenuated in the absence of IFNAR1, including PbA-induced brain sequestration of CXCR3+-activated CD8+ T cells. This was associated with reduced expression of Granzyme B, IFN-γ, IL-12Rβ2, and T-cell-attracting chemokines CXCL9 and CXCL10 in IFNAR1-/- mice, more so in the absence of IFN-γR1. Therefore, the type I IFN-α/β receptor pathway contributes to brain T-cell responses and microvascular pathology, although it is not as essential as IFN-γ for the development of cerebral malaria upon hepatic or blood-stage PbA infection. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Palomo, Jennifer
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Fauconnier, Mathilde
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Coquard, Laurie
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Gilles, Maïlys
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Meme, Sandra
France, Orleans
Cbm Centre de Biophysique Moléculaire
Szeremeta, Frédéric
France, Orleans
Cbm Centre de Biophysique Moléculaire
Fick, Lizette C.E.
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
Franetich, Jean François
France, Paris
Sorbonne Université
France, Paris
Inserm
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Jacobs, Muazzam
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
Togbé, Dieudonnée
France, Orleans
Artimmune Sas
Beloeil, Jean Claude
France, Orleans
Cbm Centre de Biophysique Moléculaire
Mazier, Dominique
France, Paris
Sorbonne Université
France, Paris
Inserm
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Ryffel, Bernhard
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
South Africa, Cape Town
Institute of Infectious Disease and Molecular Medicine
Quesniaux, Valérie F.J.
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Orleans
Université D'orléans
Statistics
Citations: 46
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1002/eji.201343327
e-ISSN:
15214141
Research Areas
Infectious Diseases