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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prenatal food supplementation fortified with multiple micronutrients increases birth length: A randomized controlled trial in rural Burkina Faso
American Journal of Clinical Nutrition, Volume 90, No. 6, Year 2009
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Description
Background: Prenatal multiple micronutrient (MMN) or balanced energy and protein supplementation has a limited effect on birth size of the offspring. Objective: The objective was to determine whether a prenatal MMN-fortified food supplement (FFS) improves anthropometric measures at birth compared with supplementation with an MMN pill alone. Design: We conducted a nonblinded, individually randomized controlled trial in 1296 pregnant women in 2 villages in rural Burkina Faso. Supplements were provided on a daily basis, and compliance was closely verified by using a community-based network of home visitors. Results: Anthropometric measures at birth were available for analysis for 87% of the 1175 live singleton deliveries enrolled. After adjustment for gestational age at birth, the FFS group had a significantly higher birth length (+4.6 mm; P = 0.001). FFS supplementation resulted in a modestly higher birth weight (+31 g; P = 0.197). Subgroup analyses showed clinically important treatment effects on birth length (+12.0 mm; P = 0.005) and on birth weight (+111 g; P = 0.133) for underweight [body mass index (in kg/m2) <18.5] pregnant women. Women with early pregnancy anemia who received FFS gave birth to longer newborns (+7.3 mm; P = 0.002) than did those who received MMN supplementation. Conclusions: The provision of FFS to pregnant women resulted in higher birth length than did MMN supplementation. For women with a suboptimal prepregnancy nutritional status, MMN supplementation should be complemented with a balanced energy and protein supplement to produce a clinical effect on birth size. The trial was registered at clinicaltrials.gov as NCT00909974. © 2009 American Society for Nutrition.
Authors & Co-Authors
Huybregts, Lieven Fernand
Belgium, Ghent
Universiteit Gent
Roberfroid, Dominique Albert
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Lanou, Hermann Biénou
Belgium, Ghent
Universiteit Gent
Burkina Faso, Ouagadougou
Institut de Recherche en Sciences de la Santé
Menten, Joris
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Méda, Nicolas Yelbomkan
Burkina Faso, Ouagadougou
Centre Muraz
van Camp, John Hendrik
Belgium, Ghent
Universiteit Gent
Kolsteren, Patrick Wilfried V.J.
Belgium, Ghent
Universiteit Gent
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Statistics
Citations: 136
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.3945/ajcn.2009.28253
ISSN:
00029165
Research Areas
Food Security
Maternal And Child Health
Sexual And Reproductive Health
Study Approach
Quantitative
Study Locations
Burkina Faso
Participants Gender
Female