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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Multicomponent synthetic polymers with viral-mimetic chemistry for nucleic acid delivery
Molecular Pharmaceutics, Volume 9, No. 1, Year 2012
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Description
The ability to deliver genetic material for therapy remains an unsolved challenge in medicine. Natural gene carriers, such as viruses, have evolved sophisticated mechanisms and modular biopolymer architectures to overcome these hurdles. Here we describe synthetic multicomponent materials for gene delivery, designed with features that mimic virus modular components and which transfect specific cell lines with high efficacy. The hierarchical nature of the synthetic carriers allows the incorporation of membrane-disrupting peptides, nucleic acid binding components, a protective coat layer, and an outer targeting ligand all in a single nanoparticle, but with functionality such that each is utilized in a specific sequence during the gene delivery process. The experimentally facile assembly suggests these materials could form a generic class of carrier systems that could be customized for many different therapeutic settings. © 2011 American Chemical Society.
Authors & Co-Authors
Soliman, Mahmoud Eid
United Kingdom, Nottingham
University of Nottingham
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Nasanit, Rujikan
United Kingdom, Birmingham
University of Birmingham
Thailand, Nakhon Pathom
Silpakorn University
Abulateefeh, Samer R.
United Kingdom, Nottingham
University of Nottingham
Allen, Stephanie J.
United Kingdom, Nottingham
University of Nottingham
Davies, Martyn C.
United Kingdom, Nottingham
University of Nottingham
Briggs, Simon S.
United Kingdom, Oxford
University of Oxford
Seymour, Leonard William
United Kingdom, Oxford
University of Oxford
Preece, Jon A.
United Kingdom, Birmingham
University of Birmingham
Grabowska, Anna M.
United Kingdom, Nottingham
University of Nottingham
Watson, Susan Anne
United Kingdom, Nottingham
University of Nottingham
Alexander, Cameron
United Kingdom, Nottingham
University of Nottingham
Statistics
Citations: 39
Authors: 11
Affiliations: 5
Identifiers
Doi:
10.1021/mp200108q
ISSN:
15438384
e-ISSN:
15438392
Research Areas
Genetics And Genomics
Health System And Policy