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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First Outbreak Response Using an Oral Cholera Vaccine in Africa: Vaccine Coverage, Acceptability and Surveillance of Adverse Events, Guinea, 2012
PLoS Neglected Tropical Diseases, Volume 7, No. 10, Article e2465, Year 2013
Notification
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Description
Background:Despite World Health Organization (WHO) prequalification of two safe and effective oral cholera vaccines (OCV), concerns about the acceptability, potential diversion of resources, cost and feasibility of implementing timely campaigns has discouraged their use. In 2012, the Ministry of Health of Guinea, with the support of Médecins Sans Frontières organized the first mass vaccination campaign using a two-dose OCV (Shanchol) as an additional control measure to respond to the on-going nationwide epidemic. Overall, 316,250 vaccines were delivered. Here, we present the results of vaccination coverage, acceptability and surveillance of adverse events.Methodology/Principal Findings:We performed a cross-sectional cluster survey and implemented adverse event surveillance. The study population included individuals older than 12 months, eligible for vaccination, and residing in the areas targeted for vaccination (Forécariah and Boffa, Guinea). Data sources were household interviews with verification by vaccination card and notifications of adverse events from surveillance at vaccination posts and health centres. In total 5,248 people were included in the survey, 3,993 in Boffa and 1,255 in Forécariah. Overall, 89.4% [95%CI:86.4-91.8%] and 87.7% [95%CI:84.2-90.6%] were vaccinated during the first round and 79.8% [95%CI:75.6-83.4%] and 82.9% [95%CI:76.6-87.7%] during the second round in Boffa and Forécariah respectively. The two dose vaccine coverage (including card and oral reporting) was 75.8% [95%CI: 71.2-75.9%] in Boffa and 75.9% [95%CI: 69.8-80.9%] in Forécariah respectively. Vaccination coverage was higher in children. The main reason for non-vaccination was absence. No severe adverse events were notified.Conclusions/Significance:The well-accepted mass vaccination campaign reached high coverage in a remote area with a mobile population. Although OCV should not be foreseen as the long-term solution for global cholera control, they should be integrated as an additional tool into the response. © 2013 Luquero et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3798604/bin/pntd.0002465.s001.pdf
Authors & Co-Authors
Luquero, Francisco Javier
France, Paris
Epicentre
Grout, Lise
France, Paris
Epicentre
Switzerland, Geneva
Medecins Sans Frontieres
Ciglenečki, Iza
Switzerland, Geneva
Medecins Sans Frontieres
Sakoba, Keita
Equatorial Guinea
Ministry of Health
France, Paris
African Cholera Surveillance Network
Traore, Bala
Guinea, Georgetown
Ministry of Health
Heile, Melat
Switzerland, Geneva
Medecins Sans Frontieres
Dialo, Alpha Amadou
Guinea, Georgetown
Ministry of Health
Itama, Christian
Switzerland, Geneva
Organisation Mondiale de la Santé
Serafini, Micaela
Switzerland, Geneva
Medecins Sans Frontieres
Legros, Dominique
Switzerland, Geneva
Medecins Sans Frontieres
Grais, Rebecca Freeman
France, Paris
Epicentre
Statistics
Citations: 66
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pntd.0002465
ISSN:
19352727
e-ISSN:
19352735
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Guinea