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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Anemia amelioration by lactose infusion during trypanosomosis could be associated with erythrocytes membrane de-galactosylation
Veterinary Parasitology, Volume 199, No. 3-4, Year 2014
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Description
African trypanosomosis is a potentially fatal disease that is caused by extracellular parasitic protists known as African trypanosomes. These parasites inhabit the blood stream of their mammalian hosts and produce a number of pathological features, amongst which is anemia. Etiology of the anemia has been partly attributed to an autoimmunity-like mediated erythrophagocytosis of de-sialylated red blood cells (dsRBCs) by macrophages. Lactose infusion to infected animals has proven effective at delaying progression of the anemia. However, the mechanism of this anemia prevention is yet to be well characterized. Here, the hypothesis of a likely induced further modification of the dsRBCs was investigated. RBC membrane galactose (RBC m-GAL) and packed cell volume (PCV) were measured during the course of experimental trypanosomosis in mice infected with Trypanosoma congolense (stb 212). Intriguingly, while the membrane galactose on the RBCs of infected and lactose-treated mice (group D) decreased as a function of parasitemia, that of the lactose-untreated infected group (group C) remained relatively constant, as was recorded for the uninfected lactose-treated control (group B) animals. At the peak of infection, the respective cumulative percent decrease in PCV and membrane galactose were 30 and 185 for group D, and 84 and 13 for group C. From this observed inverse relationship between RBCs membrane galactose and PCV, it is logical to rationalize that the delay of anemia progression during trypanosomosis produced by lactose might have resulted from an induction of galactose depletion from dsRBCs, thereby preventing their recognition by the macrophages. © 2013 Elsevier B.V.
Authors & Co-Authors
Balogun, Emmanuel Oluwadare
Nigeria, Zaria
Ahmadu Bello University
Japan, Tokyo
Graduate School of Medicine
Japan, Kyoto
Kyoto Institute of Technology
Balogun, Joshua Babalola
Nigeria, Dutse
Federal University Dutse
Yusuf, Sadiq A.
Uganda, Kampala
Kampala International University
Inuwa, Hajiya Mairo
Nigeria, Zaria
Ahmadu Bello University
Ndams, Iliya S.
Nigeria, Zaria
Ahmadu Bello University
Sheridan, P.
Japan, Tokyo
The University of Tokyo
Inaoka, Daniel Ken
Japan, Tokyo
Graduate School of Medicine
Shiba, Tomoo
Japan, Kyoto
Kyoto Institute of Technology
Harada, Shigeharu
Japan, Kyoto
Kyoto Institute of Technology
Kita, Kiyoshi
Japan, Tokyo
Graduate School of Medicine
Esievo, King Akpofure Nelson
Nigeria, Zaria
Ahmadu Bello University
Nok, Andrew Jonathan
Nigeria, Zaria
Ahmadu Bello University
Statistics
Citations: 16
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1016/j.vetpar.2013.10.013
ISSN:
03044017