Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Parasitic co-infections: Does Ascaris lumbricoides protect against Plasmodium falciparum infection?
American Journal of Tropical Medicine and Hygiene, Volume 75, No. 2, Year 2006
Notification
URL copied to clipboard!
Description
A controlled randomized trial of antihelminthic treatment was undertaken in 1996-1997 in a rural area of Madagascar where populations were simultaneously infected with Ascaris lumbricoides and Plasmodium falciparum. Levamisole was administered bimonthly to 164 subjects, randomized on a family basis, whereas 186 were controls. While levamisole proved to be highly effective in reducing Ascaris egg loads in the treated group (P < 10-3 at all bimonthly visits), subjects more than 5 years of age, treated with levamisole had a significant increase in their P. falciparum densities compared with controls (P = 0.02), whereas there was no effect of anti-helminthic treatment on children 6 months to 4 years of age. The demonstration of a clear negative interaction between Ascaris infection and malaria parasite density has important implications. Single community therapy programs to deliver treatments against several parasitic infections could avoid an increase of malaria attacks after mass treatment of ascariasis. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Brutus, Laurent
Bolivia, La Paz
Institut de Recherche Pour le Developpement Bolivia
Watier, Laurence
France, Paris
Inserm
Briand, Valérie
France, Marseille
Ird Institut de Recherche Pour le Developpement
Hanitrasoamampionona, Virginie
Madagascar, Antananarivo
Ministère de la Santé
Razanatsoarilala, Hélène
Madagascar, Antananarivo
Ministère de la Santé
Cot, Michel
France, Marseille
Ird Institut de Recherche Pour le Developpement
Statistics
Citations: 80
Authors: 6
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.2006.75.194
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Madagascar