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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Demographic characteristics and opportunistic diseases associated with attrition during preparation for antiretroviral therapy in primary health centres in Kibera, Kenya
Tropical Medicine and International Health, Volume 16, No. 5, Year 2011
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Description
Using routine data from HIV-positive adult patients eligible for antiretroviral therapy (ART), we report on routinely collected demographic characteristics and opportunistic diseases associated with pre-ART attrition (deaths and loss to follow-up). Among 2471 ART eligible patients, enrolled between January 2005 and November 2008, 446(18%) were lost to attrition pre-ART. Adjusted risk factors significantly associated with pre-ART attrition included age <35years (Odds Ratio, OR 1.4, 95% Confidence Interval, CI 1.1-1.8), severe malnutrition (OR 1.5, 95% CI 1.1-2.0), active pulmonary tuberculosis (OR 1.6, 95% CI 1.1-2.4), severe bacterial infections including severe bacterial pneumonia (OR 1.9, 95% CI 1.2-2.8) and prolonged unexplained fever (>1month), (OR 2.6, 95% CI 1.3-5.2). This study highlights a number of clinical markers associated with pre-ART attrition that could serve as 'pointers' or screening tools to identify patients who merit fast-tracking onto ART and/or closer clinical attention and follow-up. © 2011 Blackwell Publishing Ltd.
Authors & Co-Authors
Tayler-Smith, Katie
Unknown Affiliation
Zachariah, Rony R.Z.
Unknown Affiliation
Manzi, Marcel
Unknown Affiliation
Kizito, Walter
Unknown Affiliation
Vandenbulcke, Alexandra
Unknown Affiliation
Dunkley, Sophie
Unknown Affiliation
von Rege, D.
Unknown Affiliation
Reid, Tony
Unknown Affiliation
Arnould, Line
Unknown Affiliation
Suleh, Andrew Juma
Unknown Affiliation
Harries, Anthony David
Unknown Affiliation
Statistics
Citations: 23
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1111/j.1365-3156.2011.02740.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Food Security
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Case-Control Study
Study Locations
Kenya