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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Predictors of pulmonary tuberculosis treatment outcomes in South Korea: A prospective cohort study, 2005-2012
BMC Infectious Diseases, Volume 14, No. 1, Article 360, Year 2014
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Description
Background: Tuberculosis remains an important health concern in many countries. The aim of this study was to identify predictors of unfavorable outcomes at the end of treatment (EOT) and at the end of study (EOS; 40 months after EOT) in South Korea.Methods: New or previously treated tuberculosis patients were recruited into a prospective observational cohort study at two hospitals in South Korea. To identify predictors of unfavorable outcomes at EOT and EOS, logistic regression analysis was performed.Results: The proportion of multidrug-resistant tuberculosis (MDR-TB) was 8.2% in new cases and 57.9% in previously treated cases. Of new cases, 68.6% were cured, as were 40.7% of previously treated cases. At EOT, diabetes, ≥3 previous TB episodes, ≥1 significant regimen change, and MDR-TB were significantly associated with treatment failure or death. At EOS, age ≥35, body-mass index (BMI) <18.5, diabetes, and MDR-TB were significantly associated with treatment failure, death, or relapse. Among cases that were cured at EOT, age ≥50 and a BMI <18.5 were associated with subsequent death or relapse during follow-up to EOS. Treatment interruption was associated with service sector employees or laborers, bilateral lesions on chest X-ray, and previous treatment failure or treatment interruption history.Conclusions: Risk factors for poor treatment outcomes at EOT and EOS include both patient factors (diabetes status, age, BMI) and disease factors (history of multiple previous treatment episodes, MDR-TB). In this longitudinal, observational cohort study, diabetes mellitus and MDR-TB were risk factors for poor treatment outcomes and relapse. Measures to help ensure that the first tuberculosis treatment episode is also the last one may improve treatment outcomes.Trial registration: ClinicalTrials.gov ID: NCT00341601. © 2014 Choi et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Choi, Hongjo
South Korea, Changwon
International Tuberculosis Research Center
South Korea, Seoul
Korea University
Lee, Myungsun
South Korea, Changwon
International Tuberculosis Research Center
Chen, Ray Y.
United States, Bethesda
National Institutes of Health Nih
Kim, Youngran
South Korea, Changwon
International Tuberculosis Research Center
Joh, Joonsung
South Korea, Seoul
National Medical Center
Dodd, Lori Elizabeth
United States, Bethesda
National Institutes of Health Nih
Lee, Jongseok
South Korea, Changwon
International Tuberculosis Research Center
Song, Taeksun
South Korea, Changwon
International Tuberculosis Research Center
Cai, Ying
United States, Bethesda
National Institutes of Health Nih
Goldfeder, Lisa C.
United States, Bethesda
National Institutes of Health Nih
Via, L. E.
United States, Bethesda
National Institutes of Health Nih
Carroll, Matthew W.
United States, Bethesda
National Institutes of Health Nih
Barry, Clifton Earl
United States, Bethesda
National Institutes of Health Nih
Cho, Sangnae Ray
South Korea, Changwon
International Tuberculosis Research Center
South Korea, Seoul
Yonsei University College of Medicine
Statistics
Citations: 62
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1186/1471-2334-14-360
ISSN:
14712334
Research Areas
Health System And Policy
Infectious Diseases
Noncommunicable Diseases
Study Design
Cohort Study
Study Approach
Quantitative