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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Immune responses after single-dose sulphadoxine-pyrimethamine indicate underestimation of protective efficacy of intermittent preventive treatment in infants
Tropical Medicine and International Health, Volume 12, No. 10, Year 2007
Notification
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Description
Objective: To assess how intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) affects Immunoglobulin (IgG) immune responses against Plasmodium falciparum in infants from rural Ghana. Methods: Randomized, placebo-controlled and double-blinded clinical trial with participants randomized in blocks of 10 to receive either 250 mg sulphadoxine/2.5 mg pyrimethamine or placebo at the age of 3 (IPTi-1), 9 (IPTi-2) and 15 (IPTi-3) months and followed-up for 21 months. (i) Anti-P. falciparum IgG levels were measured in 180 children at the age of 9 months. (ii) Longitudinal study of the relationship between IgG levels and P. falciparum infections and/or clinical malaria in 17 naive children until they reached the age of 2 years. Results: IgG antibody levels against crude P. falciparum lysate were dependent on the frequency of preceding infections and significantly lower in children treated with SP. Conclusion: Placebo-treated children had an indifferentially higher incidence of P. falciparum infections than clinically observed, which implicates an underestimation of the protective efficacy of IPTi. IgG profiles in 17 children followed up until the age of 2 years provided no evidence for impaired immune responses after a single dose of SP within the framework of IPTi. © 2007 Blackwell Publishing Ltd.
Authors & Co-Authors
Schreiber, Nadine
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Kobbe, Robin
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Adjei, Samuel
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Adjei, Ohene
Ghana, Kumasi
Kumasi Centre for Collaborative Research in Tropical Medicine Kccr
Klinkert, Mo Quen
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
May, Juergen ü.
Germany, Hamburg
Bernhard Nocht Institut Fur Tropenmedizin Hamburg
Statistics
Citations: 15
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1111/j.1365-3156.2007.01902.x
ISSN:
13602276
e-ISSN:
13653156
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Ghana