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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Transfusion and chelation practices in sickle cell disease: A regional perspective
Pediatric Hematology and Oncology, Volume 28, No. 2, Year 2011
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Description
Although most common in tropical regions, population migration has meant that sickle cell disease is now one of the most prevalent genetic diseases worldwide. The issues and challenges faced by physicians and patients have been discussed by an international group of experts representing 4 key regions: the USA, Europe, Latin America, and the Middle East/Africa. Conclusive evidence to support the use of transfusion therapy for the prevention of stroke has resulted in key changes to patient management in all regions, and increasing numbers of patients are benefiting from this management approach. However, it is apparent that transfusion therapy is still under-utilized, largely due to concerns over iron overload, alloimmunization, limited blood supplies, and, sometimes, due to parental refusal. Once transfused, assessment and management of body iron levels can be poor, particularly in patients who are intermittently transfused. Compliance with chelation therapy regimens is a significant challenge, but new therapeutic options are likely to overcome some of the current barriers. Key requirements in all regions were considered to be the following: to provide greater physician, patient, and family education; to ensure effective transition from pediatric to adult care; and to establish national guidelines in order to ensure best practice is consistently applied. © 2011 Informa Healthcare USA, Inc.
Authors & Co-Authors
Vichinsky, Elliott P.
Unknown Affiliation
Ohene-Frempong, Kwaku O.
Unknown Affiliation
Thein, Swee Lay
Unknown Affiliation
Lopes De Castro Lobo, Clarisse
Unknown Affiliation
Inati, Adlette
Unknown Affiliation
Thompson, Alexis A.
Unknown Affiliation
Smith-Whitley, Kim
Unknown Affiliation
Kwiatkowski, Janet L.
Unknown Affiliation
Swerdlow, Paul S.
Unknown Affiliation
Porter, John B.
Unknown Affiliation
Marks, Peter W.
Unknown Affiliation
Statistics
Citations: 22
Authors: 11
Affiliations: 11
Identifiers
Doi:
10.3109/08880018.2010.505506
ISSN:
08880018
e-ISSN:
15210669
Research Areas
Genetics And Genomics
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study