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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis
Cell, Volume 157, No. 6, Year 2014
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Description
Exercise training benefits many organ systems and offers protection against metabolic disorders such as obesity and diabetes. Using the recently identified isoform of PGC1-α (PGC1-α4) as a discovery tool, we report the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure. Increasing circulating levels of Metrnl stimulates energy expenditure and improves glucose tolerance and the expression of genes associated with beige fat thermogenesis and anti-inflammatory cytokines. Metrnl stimulates an eosinophil-dependent increase in IL-4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Importantly, blocking Metrnl actions in vivo significantly attenuates chronic cold-exposure-induced alternative macrophage activation and thermogenic gene responses. Thus, Metrnl links host-adaptive responses to the regulation of energy homeostasis and tissue inflammation and has therapeutic potential for metabolic and inflammatory diseases. © 2014 Elsevier Inc.
Authors & Co-Authors
Gygi, Steven P.
United States, Boston
Harvard Medical School
Hawley, John A.
Australia, Sydney
Australian Catholic University
United Kingdom, Liverpool
Liverpool John Moores University
Spiegelman, Bruce M.
United States, Boston
Dana-farber Cancer Institute
United States, Boston
Harvard Medical School
Statistics
Citations: 730
Authors: 3
Affiliations: 5
Identifiers
Doi:
10.1016/j.cell.2014.03.065
ISSN:
00928674
Research Areas
Genetics And Genomics
Noncommunicable Diseases