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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Geographical genomics of human leukocyte gene expression variation in southern Morocco
Nature Genetics, Volume 42, No. 1, Year 2010
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Description
Studies of the genetics of gene expression can identify expression SNPs (eSNPs) that explain variation in transcript abundance. Here we address the robustness of eSNP associations to environmental geography and population structure in a comparison of 194 Arab and Amazigh individuals from a city and two villages in southern Morocco. Gene expression differed between pairs of locations for up to a third of all transcripts, with notable enrichment of transcripts involved in ribosomal biosynthesis and oxidative phosphorylation. Robust associations were observed in the leukocyte samples: cis eSNPs (P <10 -08) were identified for 346 genes, and trans eSNPs (P <10 -11) for 10 genes. All of these associations were consistent both across the three sample locations and after controlling for ancestry and relatedness. No evidence of large-effect trans-acting mediators of the pervasive environmental influence was found; instead, genetic and environmental factors acted in a largely additive manner. © 2010 Nature America, Inc. All rights reservsed.
Authors & Co-Authors
Idaghdour, Youssef
United States, Raleigh
Nc State University
Czika, Wendy
United States, Cary
Sas Institute, Inc.
Shianna, Kevin V.
United States, Durham
Duke University
Lee, Sang-hong
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Visscher, Peter M.
Australia, Brisbane
Qimr Berghofer Medical Research Institute
Martin, Hilary C.
Australia, Brisbane
The University of Queensland
Miclaus, Kelci
United States, Cary
Sas Institute, Inc.
Jadallah, Sami J.
Morocco, Agadir
Hrh Prince Sultan International Foundation for Conservation
Goldstein, David B.
United States, Durham
Duke University
Wolfinger, Russell D.
United States, Cary
Sas Institute, Inc.
Gibson, Greg C.
United States, Raleigh
Nc State University
Australia, Brisbane
The University of Queensland
Statistics
Citations: 165
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1038/ng.495
ISSN:
10614036
e-ISSN:
15461718
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Morocco