Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical and epidemiological characteristics of individuals resistant to M. tuberculosis infection in a longitudinal TB household contact study in Kampala, Uganda
BMC Infectious Diseases, Volume 14, No. 1, Article 352, Year 2014
Notification
URL copied to clipboard!
Description
Background: Despite sustained exposure to a person with pulmonary tuberculosis (TB), some M. tuberculosis (Mtb) exposed individuals maintain a negative tuberculin skin test (TST). Our objective was to characterize these persistently negative TST (PTST-) individuals and compare them to TST converters (TSTC) and individuals who are TST positive at study enrollment.Methods: During a TB household contact study in Kampala, Uganda, PTST-, TSTC, and TST + individuals were identified. PTST- individuals maintained a negative TST over a 2 year observation period despite prolonged exposure to an infectious tuberculosis (TB) case. Epidemiological and clinical characteristics were compared, a risk score developed by another group to capture risk for Mtb infection was computed, and an ordinal regression was performed.Results: When analyzed independently, epidemiological risk factors increased in prevalence from PTST- to TSTC to TST+. An ordinal regression model suggested age (p < 0.01), number of windows (p < 0.01) and people (p = 0.07) in the home, and sleeping in the same room (p < 0.01) were associated with PTST- and TSTC. As these factors do not exist in isolation, we examined a risk score, which reflects an accumulation of risk factors. This compound exposure score did not differ significantly between PTST-, TSTC, and TST+, except for the 5-15 age group (p = 0.009).Conclusions: Though many individual factors differed across all three groups, an exposure risk score reflecting a collection of risk factors did not differ for PTST-, TSTC and TST + young children and adults. This is the first study to rigorously characterize the epidemiologic risk profile of individuals with persistently negative TSTs despite close exposure to a person with TB. Additional studies are needed to characterize possible epidemiologic and host factors associated with this phenotype. © 2014 Ma et al.; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4091673/bin/1471-2334-14-352-S1.doc
Authors & Co-Authors
Ma, Ningning
United States, Cleveland
Case Western Reserve University
Zalwango, Sarah K.
Uganda, Kampala
Mulago Hospital
Malone, La Shaunda L.
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Mulago Hospital
Nsereko, Mary
Uganda, Kampala
Mulago Hospital
Wampande, Eddie Mujjwiga
Uganda, Kampala
Mulago Hospital
Thiel, Bonnie A.
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Mulago Hospital
Okware, Brenda Gloria Amo
Uganda, Kampala
Mulago Hospital
Igo, Robert P.
United States, Cleveland
Case Western Reserve University
Joloba, Moses Lutaakome
Uganda, Kampala
Mulago Hospital
Mupere, Ezekiel
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Mulago Hospital
Mayanja-Kizza, Harriet
Uganda, Kampala
Mulago Hospital
Boom, W. Henry
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Mulago Hospital
Stein, Catherine M.
United States, Cleveland
Case Western Reserve University
Uganda, Kampala
Mulago Hospital
Statistics
Citations: 52
Authors: 13
Affiliations: 2
Identifiers
Doi:
10.1186/1471-2334-14-352
e-ISSN:
14712334
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Uganda