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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
EVE/cyclosporin (etoposide, vincristine, epirubicin with high-dose cyclosporin) - Chemotherapy selected for multidrug resistance modulation
European Journal of Cancer, Volume 38, No. 18, Year 2002
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Description
Sixteen children and young adults were treated with high-dose cyclosporin combined with a combination of cytotoxics (epirubicin, vincristine and etoposide) (EVE) known to be influenced by P-glycoprotein-mediated multidrug resistance (MDR). Tumour types were neuroblastoma 3, Ewing's sarcoma 2, rhabdomyosarcoma 5, osteosarcoma 3, desmoplastic small round cell tumour 1, nephroblastoma 1, T-acute lymphoblastic leukaemia (ALL) 1. All had progressed or relapsed following at least two of the drug types included in EVE. Acute reactions to cyclosporin and myelosuppression were the major toxicities documented. Renal and hepatic toxicity was rarely severe and always transient. Partial responses (PR) were observed in 2 patients (1 rhabdomyosarcoma, 1 Ewing's sarcoma). We conclude that this combination is tolerable in heavily pretreated patients and may be suitable for further evaluation in untreated poor risk tumours. © 2002 Elsevier Science Ltd. All rights reserved.
Authors & Co-Authors
Davidson, Alan I.G.
United Kingdom, London
The Institute of Cancer Research
Pritchard-Jones, Kathy
United Kingdom, Brighton
The Royal Alex Children’s Hospital
Pinkerton, Charles Ross
United Kingdom, London
The Institute of Cancer Research
Statistics
Citations: 7
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1016/S0959-8049(02)00493-8
ISSN:
09598049
Research Areas
Cancer
Maternal And Child Health