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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Non-adherence to antiretroviral therapy in Yaounde: Prevalence, determinants and the concordance of two screening criteria
Journal of Infection and Public Health, Volume 6, No. 4, Year 2013
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Description
Purpose: To assess the prevalence and determinants of non-adherence to antiretroviral therapy (ART) as well as the concordance of two screening criteria in a major center for human immunodeficiency virus (HIV) treatment in Yaounde, Cameroon. Methods: In 2011, we conducted a cross-sectional study involving a random sample of 889 adults (age > 18 years, 67.9% women) infected with HIV who were receiving chronic care at the Yaounde Jamot Hospital. Adherence was assessed via self-administered questionnaires using the Community Programs for Clinical Research on AIDS (CPCRA) index and the Center for Adherence Support Evaluation (CASE) index. Results: The prevalence of non-adherence to ART was 22.5% based on the CPCRA index and 34.9% based on the CASE index, with a low agreement between the two indexes [kappa = 0.37 (95% confidence interval 0.31-0.44)]. Independent determinants of CPCRA-diagnosed non-adherence were as follows: being a remunerated employee [odds ratio (95% confidence interval): 1.61 (1.14-2.28)], Pentecostal Christianity [2.18 (1.25-3.80)], alcohol consumption [1.65 (1.16-2.34)] and non-adherence to cotrimoxazole prophylaxis [5.73 (3.92-8.38)]. The equivalents for CASE-diagnosed non-adherence were [1.59 (1.19-2.12)], [1.83 (1.36-2.47)], [1.70 (1.27-2.28)], respectively, in addition to association with changes to the ART regimen [1.61 (1.17-2.20)]. Conclusions: Non-adherence to ART remains high in this population. The careful evaluation of patients for the presence of determinants of non-adherence identified in this study may aid ART optimization. © 2013 King Saud Bin Abdulaziz University for Health Sciences.
Authors & Co-Authors
Pefura-Yone, Eric Walter
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Yaounde Jamot Hospital
Soh, Emmanuel
Cameroon, Yaounde
Yaounde Jamot Hospital
Kengne, Andre-Pascal Pascal
South Africa, Tygerberg
South African Medical Research Council
Balkissou, Adamou Dodo
Cameroon, Yaounde
Université de Yaoundé I
Kuaban, Christopher
Cameroon, Yaounde
Université de Yaoundé I
Cameroon, Yaounde
Yaounde Jamot Hospital
Statistics
Citations: 41
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.jiph.2013.02.003
ISSN:
18760341
e-ISSN:
1876035X
Research Areas
Health System And Policy
Infectious Diseases
Substance Abuse
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Cameroon
Participants Gender
Female