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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Bovine Staphylococcus aureus superantigens stimulate the entire T cell repertoire of cattle
Infection and Immunity, Volume 86, No. 11, Article e00505-18, Year 2018
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Description
Superantigens (SAgs) represent a diverse family of bacterial toxins that induce V-specific T cell proliferation associated with an array of important diseases in humans and animals, including mastitis of dairy cows. However, an understanding of the diversity and distribution of SAg genes among bovine Staphylococcus aureus strains and their role in the pathogenesis of mastitis is lacking. Population genomic analysis of 195 bovine S. aureus isolates representing 57 unique sequence types revealed that strains encode 2 to 13 distinct SAgs and that the majority of isolates contain 5 or more SAg genes. A genome-scale analysis of bovine reference strain RF122 revealed a complement of 11 predicted SAg genes, which were all expressed in vitro. Detection of specific antibodies in convalescent cows suggests expression of 7 of 11 SAgs during natural S. aureus infection. We determined the V T cell activation profile for all functional SAgs encoded by RF122, revealing evidence for bovine host-specific activity among the recently identified RF122-encoded SAgs SElY and SElZ. Remarkably, we discovered that some strains have evolved the capacity to stimulate the entire T cell repertoire of cattle through an array of diverse SAgs, suggesting a key role in bovine immune evasion. © 2018 Wilson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Authors & Co-Authors
Wee, Bryan A.
United Kingdom, Edinburgh
The University of Edinburgh
Seo, Keun-seok
United States, Mississippi State
Mississippi State University
Connelley, Timothy K.
United Kingdom, Edinburgh
The University of Edinburgh
Morrison, William Ivan
United Kingdom, Edinburgh
The University of Edinburgh
Fitzgerald, Julie Ross
United Kingdom, Edinburgh
The University of Edinburgh
Ireland, Cork
University College Cork
Statistics
Citations: 35
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.1128/IAI.00505-18
ISSN:
00199567
Research Areas
Health System And Policy
Study Design
Cross Sectional Study