Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Regional variation in prevalence of antibody against human T‐lymphotropic virus types I and III in Kenya, East Africa
International Journal of Cancer, Volume 35, No. 6, Year 1985
Notification
URL copied to clipboard!
Description
The prevalence of antibodies against HTLV—III and ‐I was studied among populations of 6 distinctly different regions of Kenya, an equatorial African country in which AIDS has rarely been observed. Overall, 21% of subjects had ELISA reactions suggesting the presence of antibody against HTLV‐III. The frequency of HTLV‐III antibodies was highest among the Turkana people (50%) and lowest among the Masai (8%). Prevalence increased with age but was not related to sex. The pattern of ELISA‐detected antibody against HTLV‐I was similar. The specificity of these antibodies was supported by Western blot analysis of a subset of sera with high and low ELISA ratios, in which 66% and 73% of those with ELISA ratios considered positive ( = > 5.0 in this study) also had a profile of bands consistent with HTLV‐III and HTLV‐I respectively. The antibodies detected were not cross‐reactive between HTLV‐III and HTLV—I on Western blot analysis. In a series of subjects with various parasitic and infectious diseases, patients with idiopathic splenomegaly and with schistosomiasis had a high proportion of antibodies against both HTLV‐III and HTLV‐I. This survey shows that reactivity in the ELISA HTLV‐III and HTLV‐I assays are common among Kenyans but vary considerably by region. Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Biggar, Robert John
United States, Rockville
National Cancer Institute Nci
Johnson, Bruce K.
Kenya, Nairobi
Kenya Medical Research Institute
Oster, Charles N.
Kenya, Nairobi
Kenya Medical Research Institute
Sarin, Prem S.
United States, Rockville
National Cancer Institute Nci
Ocheng, David M.
Kenya, Nairobi
Kenya Medical Research Institute
Tukei, Peter M.
Kenya, Nairobi
Kenya Medical Research Institute
Nsanze, Herbert N.
Kenya, Nairobi
Kenya Medical Research Institute
Alexander, Steven
United States, Rockville
Rorer Biotechnology, Inc.
Bodner, Anne J.
United States, Rockville
Rorer Biotechnology, Inc.
Siongok, Timothy Karap
Kenya, Nairobi
Ministry of Health Nairobi
Gallo, Robert C.
United States, Rockville
National Cancer Institute Nci
Blattiner, William A.
United States, Rockville
National Cancer Institute Nci
Statistics
Citations: 61
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1002/ijc.2910350611
ISSN:
00207136
e-ISSN:
10970215
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Multi-countries
Kenya