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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The synthesis and anticancer activity of selected diketopiperazines
Peptides, Volume 29, No. 8, Year 2008
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Description
Six selected diketopiperazines, cyclo(Gly-Val), cyclo(Gly-D-Val), cyclo(Gly-Leu), cyclo(Gly-Ile), cyclo(Phe-Cys) and cyclo(Tyr-Cys), were synthesized via various synthetic routes. Their potential to inhibit cancer cell growth in HT-29, HeLa and MCF-7 cells was determined. Cyclo(Tyr-Cys) caused the greatest inhibition in cervical carcinoma cells with near equivalent activity against HT-29 and MCF-7 cells. The other cyclic dipeptides tested were effective in the inhibition of colon, cervical and breast carcinoma cells, respectively, but the percentage inhibition was lower than for cyclo(Tyr-Cys). © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
van der Merwe, E.
South Africa, Gqeberha
Nelson Mandela University
Huang, D.
South Africa, Gqeberha
Nelson Mandela University
Peterson, D.
South Africa, Gqeberha
Nelson Mandela University
Kilian, Gareth
South Africa, Gqeberha
Nelson Mandela University
Milne, Pieter J.
South Africa, Gqeberha
Nelson Mandela University
Van de Venter, Maryna
South Africa, Gqeberha
Nelson Mandela University
Frost, Carminita Lara
South Africa, Gqeberha
Nelson Mandela University
Statistics
Citations: 50
Authors: 7
Affiliations: 1
Identifiers
Doi:
10.1016/j.peptides.2008.03.010
ISSN:
01969781
Research Areas
Cancer