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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Polymorphic variability in the interleukin (IL)-1β promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1β production
Journal of Infectious Diseases, Volume 198, No. 8, Year 2008
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Description
Interleukin (IL)-1β is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1β polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1β promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1β levels were investigated in children with parasitemia (n = 566) from western Kenya. The IL-1β promoter haplotype -31C/-511A (CA) was associated with increased risk of SMA (Hb level <6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P < .05) and reduced circulating IL-1β levels (P < .05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA (OR, 0.52 [95% CI, 0.18 -1.16]; P = .11) and elevated IL-1β production (P < .05). Compared with the non-SMA group, children with SMA had significantly lower IL-1β levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1β. The results presented demonstrate that variation in IL-1β promoter conditions susceptibility to SMA and functional changes in circulating IL-1β levels. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Ouma, Collins
United States, Albuquerque
The University of new Mexico
Kenya, Nairobi
Kenyatta University
Davenport, Gregory C.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Awandare, Gordon Akanzuwine
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
United States, Silver Springs
Walter Reed Army Institute of Research
Keller, Christopher C.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
United States, Erie
Lake Erie College of Osteopathic Medicine
Were, Tom
United States, Albuquerque
The University of new Mexico
Kenya, Nairobi
Kenyatta University
Otieno, Michael F.
Kenya, Nairobi
Kenyatta University
Vulule, John M.
Kenya, Nairobi
Kenya Medical Research Institute
Martinson, Jeremy J.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Ong'Echa, John Michael O.
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
Unm School of Medicine
Ferrell, Robert E.
United States, Pittsburgh
University of Pittsburgh Graduate School of Public Health
Perkins, Douglas Jay
United States, Albuquerque
The University of new Mexico
United States, Albuquerque
Unm School of Medicine
Statistics
Citations: 51
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1086/592055
ISSN:
00221899
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Case-Control Study
Study Locations
Kenya