Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies
Nature Genetics, Volume 38, No. 5, Year 2006
Notification
URL copied to clipboard!
Description
The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping. © 2006 Nature Publishing Group.
Authors & Co-Authors
Service, Susan K.
Unknown Affiliation
DeYoung, J.
Unknown Affiliation
Karayiorgou, Maria
Unknown Affiliation
Roos, J. L.
Unknown Affiliation
Pretorious, Herman
Unknown Affiliation
Bedoya, Gabriel De Jesús
Unknown Affiliation
Ospina-Duque, Jorge
Unknown Affiliation
Ruiz-Linarès, Andrés D.Sign©s
Unknown Affiliation
Macedo, Antonio Ferreira
Unknown Affiliation
Palha, Joana A.
Unknown Affiliation
Heutink, Peter
Unknown Affiliation
Aulchenko, Yurii S.
Unknown Affiliation
Oostra, Ben A.
Unknown Affiliation
van Duijn, Cornelia M.
Unknown Affiliation
J̈arvelin, Märjo Riitta R.
Unknown Affiliation
Varilo, Teppo
Unknown Affiliation
Peddle, Lynette J.
Unknown Affiliation
Rahman, Proton
Unknown Affiliation
Piras, Giovanna
Unknown Affiliation
Monne, Maria
Unknown Affiliation
Murray, Sarah Shaw
Unknown Affiliation
Galver, Luana M.
Unknown Affiliation
Peltonen-Palotie, Leena Johanna
Unknown Affiliation
Sabatti, Chiara
Unknown Affiliation
Collins, Andrew
Unknown Affiliation
Luben, Robert N.
Unknown Affiliation
Statistics
Citations: 282
Authors: 26
Affiliations: 21
Identifiers
Doi:
10.1038/ng1770
ISSN:
10614036
e-ISSN:
15461718
Study Design
Cross Sectional Study