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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The Relationship between RTS,S Vaccine-Induced Antibodies, CD4
+
T Cell Responses and Protection against Plasmodium falciparum Infection
PLoS ONE, Volume 8, No. 4, Article e61395, Year 2013
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Description
Vaccination with the pre-erythrocytic malaria vaccine RTS,S induces high levels of antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a biologically-motivated mathematical model of sporozoite infection fitted to data from malaria-naive adults vaccinated with RTS,S and subjected to experimental P. falciparum challenge, we characterised the relationship between antibodies, CD4+ T cell responses and protection from infection. Both anti-CSP antibody titres and CSP-specific CD4+ T cells were identified as immunological surrogates of protection, with RTS,S induced anti-CSP antibodies estimated to prevent 32% (95% confidence interval (CI) 24%-41%) of infections. The addition of RTS,S-induced CSP-specific CD4+ T cells was estimated to increase vaccine efficacy against infection to 40% (95% CI, 34%-48%). This protective efficacy is estimated to result from a 96.1% (95% CI, 93.4%-97.8%) reduction in the liver-to-blood parasite inoculum, indicating that in volunteers who developed P. falciparum infection, a small number of parasites (often the progeny of a single surviving sporozoite) are responsible for breakthrough blood-stage infections. © 2013 White et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3628884/bin/pone.0061395.s001.docx
Authors & Co-Authors
White, Michael T.
Unknown Affiliation
Bejon, Philip A.
Unknown Affiliation
Olotu, Ally Ibrahim
Unknown Affiliation
Griffin, Jamie T.
Unknown Affiliation
Riley, Eleanor M.
Unknown Affiliation
Kester, Kent E.
Unknown Affiliation
Ockenhouse, Christian F.
Unknown Affiliation
Ghani, Azra C.H.
Unknown Affiliation
Statistics
Citations: 165
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1371/journal.pone.0061395
e-ISSN:
19326203
Research Areas
Infectious Diseases