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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
The antidiarrhoeal activity of Alchornea cordifolia leaf extract
Phytotherapy Research, Volume 18, No. 11, Year 2004
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Description
Diarrhoea is a public health problem in developing countries. It is therefore important and useful to identify plants with antidiarrhoeal activity. Alchornea cordifolla is quoted by many traditional healers as a plant with this activity. The antidiarrhoeal activity of its leaf extract was investigated against castor oil induced diarrhoea in mice, using morphine as the standard reference drug. A significant (p < 0.01) dose related (100 mg/kg, 200 mg/kg, 400 mg/kg, 800 mg/kg) antidiarrhoeal activity of A. cordifolia leaf ethanol extract was observed with 800 mg/kg extract being the most effective. It delayed mouse intestinal transit accelerated by castor oil, inhibited the production of diarrhoeal faeces and modified the fluid and electrolyte transport across the colonie mucosa when administered intraluminally. Photochemical screening revealed the presence of tannins and flavonoids which may account for the increased colonic water and electrolyte reabsorption, a mechanism suggested for the antidiarrhoeal activity of A. cordifolia. Copyright © 2004 John Wiley & Sons, Ltd.
Authors & Co-Authors
Agbor, G. A.
Cameroon, Yaounde
Institute of Medical Research and Medicinal Plants Studies
Léopold, Talla
Cameroon, Yaounde
Université de Yaoundé I
Jeanne, Ngogang Y.
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 119
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1002/ptr.1446
ISSN:
0951418X
Research Areas
Environmental
Infectious Diseases