Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluation of IGL-1 preservation solution using an orthotopic liver transplantation model
World Journal of Gastroenterology, Volume 12, No. 33, Year 2006
Notification
URL copied to clipboard!
Description
Aim: To compare, in a pig liver transplantation model, the protective effect of UW with that of IGL-1, a high-sodium preservation solution containing polyethylene glycol (PEG) as an oncotic supply. Methods: All livers were harvested and grafted orthotopically according to standard techniques. The livers were washed out and preserved for 7 h in IGL-1 (n = 6) or in UW solution (n = 7) at 4°C. In a sham group (n = 4), the livers underwent a 60-min warm ischemia at 37°C. The hepatocellular injury was assessed in organ preservation solution washed out from the graft at the end of ischemic storage (before revascularization), and in serum 2 h after reperfusion and daily for up to 6 d. Results: Livers preserved in IGL-1 solution released markedly less AST than that preserved in the UW solution before and after revascularization (P < 0.05). Besides, the activity of creatine kinase-BB, a marker of sinusoidal lining cells injury, was higher in the UW group than in the IGL-1 group (P < 0.05). Histological results showed less necrotic regions in livers preserved in IGL-1 solution; however, no difference was observed for inflammation. Conclusion: IGL-1 liquid effectively protects parenchymal and non-parenchymal cells against preservation-reperfusion injuries. © 2006 The WJG Press. All rights reserved.
Authors & Co-Authors
Ben Abdennebi, Hassen
Tunisia, Monastir
Faculty of Pharmacy
Elrassi, Ziad
France, Lyon
Hopital Edouard Herriot
Scoazec, Jean Yves
France, Lyon
Hopital Edouard Herriot
Stéghens, Jean Paul
France, Lyon
Hopital Edouard Herriot
Ramella-Virieux, Silvina G.
France
Institute Georges Lopez
Boiliot, Olivier
France, Lyon
Hopital Edouard Herriot
Statistics
Citations: 38
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.3748/wjg.v12.i33.5326
ISSN:
10079327
Research Areas
Violence And Injury