Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: Results of the "cOPA" pilot randomized trial
Mucosal Immunology, Volume 4, No. 5, Year 2011
Notification
URL copied to clipboard!
Description
Intestinal mucosal immune system is an early target for human immunodeficiency virus type 1 (HIV-1) infection, resulting in CD4 + T-cell depletion, deterioration of gut lining, and fecal microbiota composition. We evaluated the effects of a prebiotic oligosaccharide mixture in highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults. In a pilot double-blind, randomized, placebo-controlled study, 57 HAART-naive HIV-1-infected patients received a unique oligosaccharide mixture (15 or 30 g short chain galactooligosaccharides/long chain fructooligosaccharides/pectin hydrolysate-derived acidic oligosaccharides (scGOS/lcFOS/pAOS) daily) or a placebo for 12 weeks. Microbiota composition improved significantly with increased bifidobacteria, decreased Clostridium coccoides/Eubacterium rectale cluster, and decreased pathogenic Clostridium lituseburense/Clostridium histolyticum group levels upon prebiotic supplementation. In addition, a reduction of soluble CD14 (sCD14), activated CD4 +/CD25 + T cells, and significantly increased natural killer (NK) cell activity when compared with control group were seen in the treatment group. The results of this pilot trial highly significantly show that dietary supplementation with a prebiotic oligosaccharide mixture results in improvement of the gut microbiota composition, reduction of sCD14, CD4 + T-cell activation (CD25), and improved NK cell activity in HAART-naive HIV-infected individuals. © 2011 Society for Mucosal Immunology.
Authors & Co-Authors
Gori, Andrea
Italy, Milan
Università Degli Studi Di Milano-bicocca
Rizzardini, Giuliano
Italy, Milan
Ospedale Luigi Sacco - Polo Universitario
Van't Land, Belinda
Netherlands, Utrecht
Universiteit Utrecht
Torti, Carlo
Italy, Brescia
Università Degli Studi Di Brescia
Quirino, Tiziana
Italy, Busto Arsizio
Azienda Ospedaliera Di Busto Arsizio
Tincati, Camilla
Italy, Milan
Ospedale San Paolo
Bandera, Alessandra
Italy, Milan
Università Degli Studi Di Milano-bicocca
Knol, Jan
Unknown Affiliation
Trabattoni, Daria Lucia
Italy, Milan
Università Degli Studi Di Milano
Bray, Dorothy H.
Unknown Affiliation
Garssen, Johan (Johan)
Netherlands, Utrecht
Universiteit Utrecht
Clerici, Mario S.
Italy, Milan
Università Degli Studi Di Milano
Statistics
Citations: 180
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1038/mi.2011.15
ISSN:
19353456
Research Areas
Disability
Infectious Diseases
Study Design
Randomised Control Trial