Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
In vitro biological activity and essential oil composition of four indigenous South African Helichrysum species
Journal of Ethnopharmacology, Volume 95, No. 2-3, Year 2004
Notification
URL copied to clipboard!
Description
Helichrysum species are used widely to treat various medical conditions. In this study, the anti-microbial, anti-oxidant (DPPH assay) and anti-inflammatory activity (5-lipoxygenase assay) of Helichrysum dasyanthum, Helichrysum felinum, Helichrysum excisum and Helichrysum petiolare were investigated. The essential oil compositions of these species were determined. The acetone and methanol extracts as well as the essential oils exhibited activity against Gram-positive bacteria, while both the methanol and acetone extracts of all four species were active in the anti-oxidant assay. The essential oils, on the other hand, displayed activity in the 5-lipoxygenase assay, which was used as an indication of anti-inflammatory activity. Two extracts exhibited promising activity in the anti-microbial assay, the acetone extract of Helichrysum dasyanthum with a MIC value of 15.63 μg/ml and the methanol extract of Helichrysum excisum with a MIC value of 62.5 μg/ml. The acetone extract of Helichrysum dasyanthum was the most active free radical scavenger in the DPPH assay (IC 50 of 9.53 μg/ml) while values for the anti-inflammatory activity of the essential oils ranged between 25 and 32 μg/ml. The essential oil compositions of three species (Helichrysum dasyanthum, Helichrysum excisum and Helichrysum petiolare) were dominated by the presence of monoterpenes such as α-pinene, 1,8-cineole and p-cymene. In the oil of Helichrysum felinum, monoterpenes were largely absent. Its profile consisted of a variety of sesquiterpenes in low concentrations with β-caryophyllene dominating. © 2004 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Lourens, Anna C.U.
South Africa, Johannesburg
University of the Witwatersrand
Ravi Sankar Reddy, Dontireddy
South Africa, Johannesburg
University of the Witwatersrand
Başer, K. Hüsnü Can
Turkey, Eskisehir
Anadolu Üniversitesi
Viljoen, Alvaro M.
South Africa, Johannesburg
University of the Witwatersrand
van Vuuren, Sandy
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 196
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.jep.2004.07.027
ISSN:
03788741