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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression
Journal of Virology, Volume 83, No. 19, Year 2009
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Description
The determinants of a broad neutralizing antibody (NAb) response and its effect on human immunodeficiency virus type 1 (HIV-1) disease progression are not well defined, partly because most prior studies of a broad NAb response were cross-sectional. We examined correlates of NAb response breadth among 70 HIV-infected, antiretroviral-naïve Kenyan women from a longitudinal seroincident cohort. NAb response breadth was measured 5 years after infection against five subtype A viruses and one subtype B virus. Greater NAb response breadth was associated with a higher viral load set point and greater HIV-1 env diversity early in infection. However, greater NAb response breadth was not associated with a delayed time to a CD4+ T-cell count of <200, antiretroviral therapy, or death. Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection. Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Piantadosi, Anne L.
United States, Seattle
Fred Hutchinson Cancer Research Center
Panteleeff, Dana De Vange
United States, Seattle
Fred Hutchinson Cancer Research Center
Blish, Catherine A.
United States, Seattle
Fred Hutchinson Cancer Research Center
United States, Seattle
University of Washington
Baeten, Jared M.
United States, Seattle
University of Washington
Jaoko, Walter G.
Kenya, Nairobi
University of Nairobi
McClelland, Raymond Scott
United States, Seattle
University of Washington
Kenya, Nairobi
University of Nairobi
Overbaugh, Julie M.
United States, Seattle
Fred Hutchinson Cancer Research Center
Statistics
Citations: 189
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1128/JVI.01149-09
ISSN:
0022538X
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female