Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Up-regulation of Notch-1 in psoriasis: An immunohistochemical study
Annals of Diagnostic Pathology, Volume 16, No. 3, Year 2012
Notification
URL copied to clipboard!
Description
The Notch pathway plays a key role in differentiation, proliferation, and influencing cell fate decision in multiple organisms and tissues including the epidermis and its appendages. The role of Notch-1 in psoriasis has not been widely evaluated; therefore, the current study aimed to evaluate its role in etiopathogenesis of this common skin disease. The current study used immunohistochemical technique to evaluate Notch-1 expression in 35 lesional biopsies of patients having chronic plaque psoriasis in comparison with normal skin biopsies, representing the control group. Notch-1 was expressed in the epidermis of both normal and psoriatic skins; however, the intensity was in favor of psoriatic lesion, and the nuclear form of Notch-1 was more frequently and diffusely seen in psoriasis. Exacerbation of psoriasis as assessed by the Psoriasis Area and Severity Index score was significantly associated with intense (P =.005) and nuclear form of Notch-1 expression (P =.0001). The nuclear form of Notch-1 was also correlated with female sex (P =.043). From this study, up-regulation and not down-regulation of Notch-1 may have a role in pathogenesis of psoriasis. The nuclear form is responsible for the exacerbation of symptoms, and it is the one that may disappear by the effect of psoralen and ultraviolet A radiation (PUVA) therapy. © 2012 Elsevier Inc.
Authors & Co-Authors
Abdou, A. G.
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Maraee, Alaa Hassan
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Sharaf, Amany
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Elnaidany, Nada Farag
Egypt, 6th October
Faculty of Pharmacy
Statistics
Citations: 20
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.anndiagpath.2011.09.005
ISSN:
10929134
e-ISSN:
15328198
Research Areas
Cancer
Study Design
Randomised Control Trial
Participants Gender
Female