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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The 5q31 region in two African populations as a facet of natural selection by infectious diseases
Russian Journal of Genetics, Volume 49, No. 2, Year 2013
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Description
Cases of extreme natural selection could lead either to rapid fixation or extinction of alleles depending on the population structure and size. It may also manifest in excess of heterozygosity and the locus concerned will be displaying such drastic features of allele change. We suspect the 5q31 in chromosome 5 to mirror situation of such extreme natural selection particularly that the region encompasses genes of type 2 cytokine known to associate with a number of infectious and non-infectious diseases. We typed two sets of single nucleotide polymorphisms (SNPS) in two populations: an initial limited set of only 4 SNP within the genes of IL-4, IL-13, IL-5 and IL-9 in 108 unrelated individuals and a replicating set of 14 SNP in 924 individuals from the same populations with disregard to relatedness. The results suggest the 5q31 area to be under intense selective pressure as indicated by marked heterozygosity independent of Linkage Disequilibrium (LD); difference in heterozygosity, allele, and haplotype frequencies between generations and departure from Hardy-Weinberg expectations (DHWE). The study area is endemic for several infectious diseases including malaria and visceral leishmaniasis (VL). Malaria caused by Plasmodium falciparum, however, occurs mostly with mild clinical symptoms in all ages, which makes it unlikely to account for these indices. The strong selection signals seems to emanate from recent outbreaks of VL which affected both populations to varying extent. © 2013 Pleiades Publishing, Ltd.
Authors & Co-Authors
Elhassan, Abdelbadea A.M.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Hussein, Ayman A.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
United Kingdom, Cambridge
The Malariagen Consortium
Mohamed, H. S.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Rockett, Kirk A.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Cambridge
The Malariagen Consortium
Kwiatkowski, Dominic P.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
United Kingdom, Hinxton
Wellcome Sanger Institute
United Kingdom, Cambridge
The Malariagen Consortium
el-Hassan, Ahmed Mohamed A.
Sudan, Khartoum
Institute of Endemic Diseases Sudan
Ibrahim, Muntaser Eltayeb
Sudan, Khartoum
Institute of Endemic Diseases Sudan
United Kingdom, Cambridge
The Malariagen Consortium
Statistics
Citations: 7
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1134/S1022795413020051
ISSN:
10227954
e-ISSN:
16083369
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study