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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-saharan Africans
Journal of Infectious Diseases, Volume 209, No. 10, Year 2014
Notification
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Description
Objective. We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples. Methods. Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls. Results. TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative controls with high but not low HIV-1 exposure (odds ratio [OR] = 0.7; P = .03 and OR = 0.9, P = .5, respectively). TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acquisition. TLR8 1A/G reduced disease progression. Conclusions. TLR SNPs impact HIV-1 outcomes with epidemiologic factors modifying these relationships. © 2013 The Author.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3997584/bin/supp_209_10_1623__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC3997584/bin/supp_jit807_jit807supp_table1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC3997584/bin/supp_jit807_jit807supp_table2.pdf
Authors & Co-Authors
MacKelprang, Romel D.
Unknown Affiliation
Bigham, Abigail W.
United States, Ann Arbor
University of Michigan, Ann Arbor
Celum, Connie L.
Unknown Affiliation
Bruyn, Guy De
South Africa, Johannesburg
University of the Witwatersrand
Beima-Sofie, Kristin M.
Unknown Affiliation
John-Stewart, Grace C.
Unknown Affiliation
Ronald, Allan R.
Canada, Winnipeg
University of Manitoba
Mugo, Nelly Rwamba
Kenya, Nairobi
University of Nairobi
Buckingham, Kati J.
Unknown Affiliation
Bamshad, Michael J.
Unknown Affiliation
Mullins, James I.
United States, Seattle
University of Washington
McElrath, Margaret Juliana
United States, Seattle
Statistical Center for Hiv/aids Research and Prevention
United States, Seattle
Fred Hutchinson Cancer Research Center
Lingappa, Jairam R.
Unknown Affiliation
Statistics
Citations: 34
Authors: 13
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/jit807
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Case-Control Study