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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Persistent and Emerging Pneumococcal Carriage Serotypes in a Rural Gambian Community After 10 Years of Pneumococcal Conjugate Vaccine Pressure
Clinical Infectious Diseases, Volume 73, No. 11, Year 2021
Notification
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Description
Background. The continuing impact of pneumococcal conjugate vaccines (PCVs) in regions with high pneumococcal transmission is threatened by the persistence of vaccine serotypes (VTs) and the emergence of nonvaccine serotypes (NVTs). Methods. In 2016, we conducted a cross-sectional carriage survey (CSS5) in a community where PCV7 was first introduced in 2006 during a cluster-randomized trial conducted before nationwide introduction of PCV7 (2009) and PCV13 (2011). We estimated prevalence of PCV13 VT and NVT by age and compared these with earlier surveys before (CSS0), during (CSS1-3), and after the trial but before PCV13 (CSS4). Genomic analysis was conducted for the nontypeable pneumococci. Results. Prevalence of PCV13 VT carriage decreased during the 10 years between CSS0 and CSS5 across all age groups (67.6% to 13.5%, P < .001; 59.8% to 14.4%, P < .001; 43.1% to 17.9%, P < .001; and 24.0% to 5.1%, P < .001, in <2, 2–4, 5–14, and ≥15 years, respectively). However, there was no difference between CSS4 and CSS5 in children ≥2 years and adults (children <2 years, no data). The prevalence of PCV13 NVT increased between CSS0 and CSS5 for children <2 years but decreased in older children and adults. In CSS5, serotypes 3, 6A, and 19F were the most common VT and nontypeable isolates were the most common NVT. Among nontypeable isolates, 73.0% lost the ability to express a capsule. Of these, 70.8% were from a VT background. Conclusions. The decrease in PCV13 VT that has occurred since the introduction of PCV13 appears to have plateaued. Significant carriage of these serotypes remains in all age groups. © The Author(s) 2020.
Authors & Co-Authors
Usuf, Effua Abigail
United Kingdom, London
London School of Hygiene & Tropical Medicine
Bottomley, Christian
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gladstone, Rebecca A.
United Kingdom, Hinxton
Wellcome Sanger Institute
Bojang, Ebrima
United Kingdom, London
London School of Hygiene & Tropical Medicine
Jawneh, Kaddijatou
United Kingdom, London
London School of Hygiene & Tropical Medicine
Cox, Isatou Jagne
United Kingdom, London
London School of Hygiene & Tropical Medicine
Jallow, Edrissa
United Kingdom, London
London School of Hygiene & Tropical Medicine
Bojang, Abdoulie
United Kingdom, London
London School of Hygiene & Tropical Medicine
Greenwood, Brian M.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Adegbola, Richard A.
Unknown Affiliation
Bentley, Stephen D.
United Kingdom, Hinxton
Wellcome Sanger Institute
Hill, Philip C.
New Zealand, Dunedin
University of Otago
Roca, Anna
United Kingdom, London
London School of Hygiene & Tropical Medicine
Statistics
Citations: 2
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1093/cid/ciaa856
ISSN:
10584838
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Study Approach
Quantitative