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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
ANO1 contributes to Angiotensin-II-activated Ca
2+
-dependent Cl
-
current in human atrial fibroblasts
Journal of Molecular and Cellular Cardiology, Volume 68, Year 2014
Notification
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Description
Cardiac fibroblasts are an integral part of the myocardial tissue and contribute to its remodelling. This study characterises for the first time the calcium-dependent chloride channels (CaCC) in the plasma membrane of primary human atrial cardiac fibroblasts by means of the iodide efflux and the patch clamp methods. The calcium ionophore A23187 and Angiotensin II (Ang II) activate a chloride conductance in cardiac fibroblasts that shares pharmacological similarities with calcium-dependent chloride channels. This chloride conductance is depressed by RNAi-mediated selective Anoctamine 1 (ANO1) but not by Anoctamine 2 (ANO2) which has been revealed as CaCC and is inhibited by the selective ANO1 inhibitor, T16inh-A01. The effect of Ang II on anion efflux is mediated through AT1 receptors (with an EC50=13.8±1.3nM). The decrease of anion efflux by calphostin C and bisindolylmaleimide I (BIM I) suggests that chloride conductance activation is dependent on PKC. We conclude that ANO1 contributes to CaCC current in human cardiac fibroblasts and that this is regulated by Ang II acting via the AT1 receptor pathway. © 2014 Elsevier Ltd.
Authors & Co-Authors
El Chemaly, Antoun
France, Poitiers
Universite de Poitiers
Norez, Caroline
France, Poitiers
Universite de Poitiers
Magaud, Christophe
France, Poitiers
Universite de Poitiers
Bescond, Jocelyn
France, Poitiers
Universite de Poitiers
Chatelier, Aurelien
France, Poitiers
Universite de Poitiers
Farès, Nassim A.
Lebanon, Beirut
Faculté de Médecine
Findlay, Ian
France, Tours
Université de Tours
Jayle, Christophe
France, Poitiers
Centre Hospitalier Universitaire de Poitiers
Becq, Frédéric
France, Poitiers
Universite de Poitiers
Faivre, Jean François
France, Poitiers
Universite de Poitiers
Bois, Patrick
France, Poitiers
Universite de Poitiers
Statistics
Citations: 17
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1016/j.yjmcc.2013.12.027
ISSN:
00222828
e-ISSN:
10958584
Research Areas
Noncommunicable Diseases