Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Sources of variability in determining malaria parasite density by microscopy
American Journal of Tropical Medicine and Hygiene, Volume 73, No. 3, Year 2005
Notification
URL copied to clipboard!
Description
Enumeration of parasites by microscopic examination of blood smears is the only method available for quantifying parasitemia in infected blood. However, the sources and scale of error inherent in this technique have not been systematically investigated. Here we use data collected in outpatient clinics in Peru and Thailand to elucidate important sources of variation in parasite density measurements. We show that discrepancies between readings from two independent microscopists and multiple readings from a single microscopist are inversely related to the density of the infection. We present an example of how differences in reader technique, specifically the number of white blood cells counted, can contribute to the differences between readings. We discuss the implications of this analysis for field studies and clinical trials. Copyright © 2005 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
O'Meara, Wendy Prudhomme
United States, Bethesda
National Institutes of Health Nih
McKenzie, F. Ellis
United States, Bethesda
National Institutes of Health Nih
Magill, Alan J.
United States, Silver Spring
Walter Reed Army Institute of Research
Lucas, Carmen M.
Peru, Lima
Naval Medical Research Unit No. 6
Wongsrichanalai, Chansuda
Indonesia, Jakarta
U.s. Naval Medical Research Unit No. 2, Jakarta
Statistics
Citations: 68
Authors: 5
Affiliations: 5
Identifiers
Doi:
10.4269/ajtmh.2005.73.593
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases