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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First-Year experience of chemotherapy for advanced retinoblastoma in Tanzania: Disease profile, outcomes, and challenges in 2008
Journal of Pediatric Ophthalmology and Strabismus, Volume 49, No. 3, Year 2012
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Description
Purpose: To examine the profile of retinoblastoma in a national tertiary referral center in Tanzania and to report first-year outcomes of its treatment using chemotherapy. Methods: All patients with retinoblastoma referred in 2008 were included. Disease was classified on clinical grounds as ocular, orbital, or metastatic. Those with ocular and orbital disease received chemotherapy. Remission was the main outcome measure and defined as absence of disease at the end of treatment. Results: In 2008, 37 patients (20 males and 17 females) with retinoblastoma were referred to Ocean Road Cancer Institute. The mean delay from the first sign of disease to presentation at hospital was 10.4 ± 8.7 months. Disease was ocular in 32% (12 of 37), orbital in 57% (21 of 37), and metastatic in 11% (4 of 37). Of those with ocular disease, 67% (8 of 12) completed chemotherapy and all (8 of 8) achieved remission. In contrast, 48% (10 of 21) with orbital disease completed chemotherapy and only 50% (5 of 10) achieved remission. The difference in outcome between the groups was statistically significant (P =.001, Fisher exact test). Conclusion: The profile of retinoblastoma in Tanzania is skewed toward severe invasive disease. Despite the introduction of chemotherapy, further improvements in mortality and morbidity can only be achieved through emphasis on early detection. © SLACK Incorporated.
Authors & Co-Authors
Carrim, Zia I.
United Kingdom, Leeds
St James's University Hospital
Kajaige, Jane
Unknown Affiliation
Bowman, Richard J.C.
Tanzania, Dar es Salaam
Ccbrt Hospital
Lavy, Timothy
Tanzania, Dar es Salaam
Ccbrt Hospital
United Kingdom, Glasgow
Royal Hospital for Sick Children
Scanlan, Patricia
Unknown Affiliation
Statistics
Citations: 7
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.3928/01913913-20110809-01
ISSN:
01913913
Research Areas
Cancer
Health System And Policy
Study Locations
Tanzania
Participants Gender
Female