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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The impact of interleukin 28b gene polymorphism on the virological response to combined pegylated interferon and ribavirin therapy in chronic HCV genotype 4 infected Egyptian patients using data mining analysis
Hepatitis Monthly, Volume 13, No. 7, Year 2013
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Description
Background: Chronic HCV represents one of the common causes of chronic liver disease worldwide with Egypt having the highest prevalence, namely genotype 4. Interleukin IL-28B gene polymorphism has been shown to relate to HCV treatment response, mainly in genotype1. Objectives: We aim to evaluate the predictive power of the rs12979860 IL28B SNP and its protein for treatment response in genotype 4 Egyptian patients by regression analysis and decision tree analysis. Patients and Methods: The study included 263 chronic HCV Egyptian patients receiving peg-interferon and ribavirin therapy. Patients were classified into 3 groups; non responders (83patients), relapsers (76patients) and sustained virological responders (104 patients). Serum IL 28 B was performed, DNA was extracted and analyzed by direct sequencing of the SNP rs 12979860 of IL28B gene. Results: CT, CC and TT represented 56%, 25% and 19% of the patients, respectively. Absence of C allele (TT genotype) was significantly baseline alpha fetoprotein (AFP ≤ 2.68 ng/ml) was the variable of initial split (the strongest predictor of response) confirmed by regression correlated with the early failure of response while CC was associated with sustained virological response. The decision tree showed that analysis. Patients with TT genotype had the highest probability of failure of response. Conclusions: Absence of the C allele was significantly associated with failure of response. The presence of C allele was associated with a favorable outcome. AFP is a strong baseline predictor of HCV treatment response. A decision tree model is useful for predicting the probability of response to therapy. © 2013, Kowsar Corp.; Licensee Kowsar Ltd.
Authors & Co-Authors
Khairy, Marwa
Egypt, Cairo
Faculty of Medicine
Fouad, Rabab
Egypt, Cairo
Faculty of Medicine
Mabrouk, Mahasen Abd El Rahman
Egypt, Cairo
Faculty of Medicine
Elakel, Wafaa Ahmed
Egypt, Cairo
Faculty of Medicine
Awad, Abubakr Bakr Hussein
Egypt, Giza
Cairo University
Salama, Rabab Maamoun
Egypt, Cairo
Faculty of Medicine
Elnegouly, Mayada Mohamed
Egypt, Cairo
Faculty of Medicine
Shaker, O. Gamil
Egypt, Giza
Cairo University
Statistics
Citations: 28
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.5812/hepatmon.10509
ISSN:
1735143X
e-ISSN:
17353408
Research Areas
Environmental
Genetics And Genomics
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Egypt