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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Radiochemistry on chip: Towards dose-on-demand synthesis of PET radiopharmaceuticals
Lab on a Chip, Volume 13, No. 12, Year 2013
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Description
We have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-d-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40-80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals. © 2013 The Royal Society of Chemistry.
Authors & Co-Authors
Arima, Valentina
Italy, Rome
Consiglio Nazionale Delle Ricerche
Pascali, Giancarlo
Italy, Pisa
Istituto Di Fisiologia Clinica Del Cnr
Australia, Sydney
Australian Nuclear Science and Technology Organisation
Lade, Oliver
Germany, Munich
Siemens ag
Kretschmer, Hans R.
Germany, Munich
Siemens ag
Bernsdorf, Ingo
Germany, Munich
Siemens ag
Hammond, Victoria
United Kingdom, Hull
University of Hull
Watts, Paul
United Kingdom, Hull
University of Hull
South Africa, Gqeberha
Nelson Mandela University
De Leonardis, Francesco
United Kingdom, Hull
University of Hull
Tarn, Mark D.
United Kingdom, Hull
University of Hull
Pamme, Nicole
United Kingdom, Hull
University of Hull
Cvetkovic, Benjamin Z.
Switzerland, Zurich
Eth Zürich
Dittrich, Petra S.
Switzerland, Zurich
Eth Zürich
Vasovic, Nikola
Ireland, Cork
Tyndall National Institute
Duane, Russell
Ireland, Cork
Tyndall National Institute
Jaksic, Aleksandar
Ireland, Cork
Tyndall National Institute
Zacheo, Antonella
Italy, Rome
Consiglio Nazionale Delle Ricerche
Italy, Lecce
Università Del Salento
Zizzari, Alessandra
Italy, Rome
Consiglio Nazionale Delle Ricerche
Marra, Lucia
Italy, Rome
Consiglio Nazionale Delle Ricerche
Perrone, Elisabetta
Italy, Rome
Consiglio Nazionale Delle Ricerche
Salvadori, Piero A.
Italy, Pisa
Istituto Di Fisiologia Clinica Del Cnr
Rinaldi, R.
Italy, Rome
Consiglio Nazionale Delle Ricerche
Italy, Lecce
Università Del Salento
Statistics
Citations: 61
Authors: 21
Affiliations: 9
Identifiers
Doi:
10.1039/c3lc00055a
ISSN:
14730197
e-ISSN:
14730189