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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Virus-encoded miRNAs in Ebola virus disease
Scientific Reports, Volume 8, No. 1, Article 6480, Year 2018
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Description
Ebola virus (EBOV) is a negative-strand RNA virus that replicates in the cytoplasm and causes an often-fatal hemorrhagic fever. EBOV, like other viruses, can reportedly encode its own microRNAs (miRNAs) to subvert host immune defenses. miRNAs are short noncoding RNAs that can regulate gene expression by hybridizing to multiple mRNAs, and viral miRNAs can enhance viral replication and infectivity by regulating host or viral genes. To date, only one EBOV miRNA has been examined in human infection. Here, we assayed mouse, rhesus macaque, cynomolgus macaque, and human samples infected with three EBOV variants for twelve computationally predicted viral miRNAs using RT-qPCR. Ten miRNAs aligned to EBOV variants and were detectable in the four species during disease with several viral miRNAs showing presymptomatic amplification in animal models. miRNA abundances in both the mouse and nonhuman primate models mirrored the human cohort, with miR-1-5p, miR-1-3p, and miR-T3-3p consistently at the highest levels. These striking similarities in the most abundant miRNAs during infection with different EBOV variants and hosts indicate that these miRNAs are potential valuable diagnostic markers and key effectors of EBOV pathogenesis. © 2018 The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC5915558/bin/41598_2018_23916_MOESM1_ESM.docx
Authors & Co-Authors
Honko, Anna N.
Unknown Affiliation
Wollen-Roberts, Suzanne E.
Unknown Affiliation
Wauquier, Nadia
United States, San Francisco
Metabiota, Inc.
O'Hearn, Aileen E.
United States, Fort Detrick
U.s. Army Medical Research Institute of Infectious Diseases
Johnson, Joshua C.
Unknown Affiliation
Botto, Miriam A.
Unknown Affiliation
Bangura, James J.
United States, San Francisco
Metabiota, Inc.
Coomber, Moinya Ruth
United States, San Francisco
Metabiota, Inc.
Pitt, Margaret Louise M.
Unknown Affiliation
Gonzalez, J. P.
United States, San Francisco
Metabiota, Inc.
United States, Manhattan
Kansas State University
Schoepp, Randal J.
United States, Fort Detrick
U.s. Army Medical Research Institute of Infectious Diseases
Minogue, Timothy Devin
United States, Fort Detrick
U.s. Army Medical Research Institute of Infectious Diseases
Statistics
Citations: 27
Authors: 12
Affiliations: 3
Identifiers
Doi:
10.1038/s41598-018-23916-z
ISSN:
20452322
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study