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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2
BMC Systems Biology, Volume 5, Article 8, Year 2011
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Description
Metabolic reconstructions (MRs) are common denominators in systems biology and represent biochemical, genetic, and genomic (BiGG) knowledge-bases for target organisms by capturing currently available information in a consistent, structured manner. Salmonella enterica subspecies I serovar Typhimurium is a human pathogen, causes various diseases and its increasing antibiotic resistance poses a public health problem.Results: Here, we describe a community-driven effort, in which more than 20 experts in S. Typhimurium biology and systems biology collaborated to reconcile and expand the S. Typhimurium BiGG knowledge-base. The consensus MR was obtained starting from two independently developed MRs for S. Typhimurium. Key results of this reconstruction jamboree include i) development and implementation of a community-based workflow for MR annotation and reconciliation; ii) incorporation of thermodynamic information; and iii) use of the consensus MR to identify potential multi-target drug therapy approaches.Conclusion: Taken together, with the growing number of parallel MRs a structured, community-driven approach will be necessary to maximize quality while increasing adoption of MRs in experimental design and interpretation. © 2011 Thiele et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Thiele, Ines
Iceland, Reykjavik
Haskoli Islands
Charusanti, Pep
United States, La Jolla
University of California, San Diego
Chen, Fengchi
Taiwan, Zhunan
National Health Research Institutes Taiwan
Hsiung, Chaoagnes
Taiwan, Zhunan
National Health Research Institutes Taiwan
De Keersmaecker, Sigrid C.J.
Belgium, Leuven
Ku Leuven
Marchal, Kathleen
Belgium, Leuven
Ku Leuven
Reed, Jennifer L.
United States, Madison
University of Wisconsin-madison
Swainston, Neil
United Kingdom, Manchester
The University of Manchester
Palsson, Bernhard Ø.
United States, La Jolla
University of California, San Diego
Bumann, Dirk
Switzerland, Basel
Universitat Basel
Statistics
Citations: 111
Authors: 10
Affiliations: 13
Identifiers
Doi:
10.1186/1752-0509-5-8
ISSN:
17520509
Research Areas
Genetics And Genomics
Infectious Diseases
Noncommunicable Diseases