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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Salivary cortisol day curves in addison's disease in patients on hydrocortisone replacement
Hormone and Metabolic Research, Volume 45, No. 1, Year 2013
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Description
Using salivary cortisol (SC) measurements, cortisol exposure in Addison's disease patients on hydrocortisone replacement was determined and compared with healthy controls. Cortisol pharmacokinetics was assessed in 31 patients with Addison's disease on replacement hydrocortisone doses (median daily dose 20 mg; range 5-50 mg) and 30 healthy control subjects. Saliva samples (n=16) were collected between 08:00 and 00:00 h in 1 day, using a passive drool technique. Cortisol exposure was evaluated by noncompartmental approach. In the patients, cortisol exposure was significantly higher than in controls: median inter-quartile range (IQR) peak cortisol (C 174.5 (59.3-837.0) vs. 6.50 (4.7-19.3) nmol/l, p=0.0001; area under the curve (AUC) 390.1 (177.1-928.9) vs. 21.4 (14.6-28.4) minutes*nmol/l, p=0.0001, trough cortisol level (C 0.49 (0.49-0.96) vs. 0.49 (0.49-0.49) nmol/l, p=0.02, occurring at 480.0 (0.1-660.0) vs. 405.0 (180.0-570.0) min, p=0.56. First peak cortisol was 174.5 (53.0-754.7) vs. 6.27 (3.90-8.47) nmol/l, p=0.0001 and second peak cortisol 18.90 (5.22-76.9) vs. 3.12 (1.76-4.79) nmol/l, p=0.0001. The time to first peak cortisol differed between the 2 groups, 30 (30-75) vs. 0.1 (0.1-30) minutes; p=0.0001. At doses studied, hydrocortisone replacement therapy results in cortisol pharmacokinetics being markedly different from endogenous cortisol profiles in healthy control subjects. Addison's disease patients had significantly higher SC levels compared to healthy control subjects. © Georg Thieme Verlag KG Stuttgart New York.
Authors & Co-Authors
Ross, Ian Louis
South Africa, Cape Town
University of Cape Town
Levitt, Naomi S.
South Africa, Cape Town
University of Cape Town
van der Walt, Jan Stefan
South Africa, Cape Town
University of Cape Town
Sweden, Uppsala
Uppsala Universitet
Schatz, Desmond A.
United States, Gainesville
University of Florida
Johannsson, Gudmundur F.
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Haarburger, David H.
South Africa, Cape Town
University of Cape Town
Pillay, Tahir S.
South Africa, Cape Town
University of Cape Town
South Africa, Durban
University of Kwazulu-natal
Statistics
Citations: 16
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1055/s-0032-1321855
ISSN:
00185043
e-ISSN:
14394286