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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Analysis of antibodies directed against merozoite surface protein 1 of the human malaria parasite Plasmodium falciparum
Infection and Immunity, Volume 74, No. 2, Year 2006
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Description
The 190-kDa merozoite surface protein 1 (MSP-1) of Plasmodium falciparum, an essential component in the parasite's life cycle, is a primary candidate for a malaria vaccine. Rabbit antibodies elicited by the heterologously produced MSP-1 processing products p83, p30, p38, and p42, derived from strain 3D7, were analyzed for the potential to inhibit in vitro erythrocyte invasion by the parasite and parasite growth. Our data show that (i) epitopes recognized by antibodies, which inhibit parasite replication, are distributed throughout the entire MSP-1 molecule; (ii) when combined, antibodies specific for different regions of MSP-1 inhibit in a strictly additive manner; (iii) anti-MSP-1 antibodies interfere with erythrocyte invasion as well as with the intraerythrocytic growth of the parasite; and (iv) antibodies raised against MSP-1 of strain 3D7 strongly cross-inhibit replication of the heterologous strain FCB-1. Accordingly, anti-MSP-1 antibodies appear to be capable of interfering with parasite multiplication at more than one level. Since the overall immunogenicity profile of MSP-1 in rabbits closely resembles that found in sera of Aotus monkeys immunized with parasite-derived MSP-1 and of humans semi-immune to malaria from whom highly inhibiting antigen-specific antibodies were recovered, we consider the findings reported here to be relevant for the development of MSP-1-based vaccines against malaria. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Woehlbier, Ute
Germany, Heidelberg
Universität Heidelberg
Epp, Christian
Germany, Heidelberg
Universität Heidelberg
Kauth, Christian W.
Germany, Heidelberg
Universität Heidelberg
Lutz, Rolf
Germany, Heidelberg
Universität Heidelberg
Long, Carole A.
United States, Bethesda
National Institute of Allergy and Infectious Diseases Niaid
Coulibaly, Boubacar
Burkina Faso, Nouna
Centre de Recherche en Sante de Nouna
Kouyaté, Bocar A.
Burkina Faso, Nouna
Centre de Recherche en Sante de Nouna
Arev́alo-Herrera, Myriam
Colombia, Cali
Centro Internacional de Vacunas
Herrera, Sócrates V.
Colombia, Cali
Centro Internacional de Vacunas
Bujard, Hermann
Germany, Heidelberg
Universität Heidelberg
Statistics
Citations: 85
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1128/IAI.74.2.1313-1322.2006
ISSN:
00199567
Research Areas
Infectious Diseases