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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
NT-proBNP, C-Reactive Protein and Soluble uPAR in a Bi-Ethnic Male Population: The SAfrEIC Study
PLoS ONE, Volume 8, No. 3, Article e58506, Year 2013
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Description
Objective and design: This cross-sectional study aimed to investigate associations between a marker of cardiac strain, the N-terminal prohormone B-type natriuretic peptide (NT-proBNP), and inflammation as reflected by either a conventional or novel inflammatory marker in a bi-ethnic South African cohort. Methods and subjects: We measured NT-proBNP, C-reactive protein (CRP) and plasma-soluble urokinase plasminogen activator receptor (suPAR) levels along with conventional biomarkers in black (n = 117) and white (n = 116) men. Results: NT-proBNP, CRP and suPAR levels were higher in black compared to white men. NT-proBNP was significantly associated with both CRP (r = 0.38; p = 0.001) and suPAR (r = 0.42; p<0.001) in black men only. After full adjustment in multiple regression analyses, the above associations of NT-proBNP with CRP (β = 0.199; p = 0.018) and suPAR (β = 0.257; p<0.01) were confirmed in black men. Conclusion: These results suggest that a low-grade inflammatory state as reflected by both a conventional and novel marker of inflammation may contribute to higher cardiovascular risk as reflected by the associations obtained with a marker of cardiac strain in black South African men. © 2013 Kruger et al.
Authors & Co-Authors
Kruger, Ruan
South Africa, Potchefstroom
North-west University
Schutte, Rudolph
South Africa, Potchefstroom
North-west University
Huisman, Hugo Willem
South Africa, Potchefstroom
North-west University
Hindersson, Peter
Denmark, Hjorring
Sygehus Vendsyssel - Hjørring
Olsen, Michael Hecht
South Africa, Potchefstroom
North-west University
Denmark, Odense
Odense Universitetshospital
Eugen-Olsen, Jesper
Denmark, Copenhagen
Københavns Universitet
Schutte, Aletta E.
South Africa, Potchefstroom
North-west University
Statistics
Citations: 27
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0058506
e-ISSN:
19326203
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Participants Gender
Male