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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Plasmodium falciparum parasite infection prevalence from a household survey in Zambia using microscopy and a rapid diagnostic test: Implications for monitoring and evaluation
Acta Tropica, Volume 112, No. 3, Year 2009
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Description
This paper presents estimates of P. falciparum infection prevalence in children under 5 years old in the context of a population-based household survey in Luangwa District (Lusaka Province), Zambia, an area where greater than 75% of households possess at least one insecticide-treated mosquito net (ITN). The sensitivity and specificity of an HRP-2 rapid diagnostic test (RDT) (ICT Malaria Pf®) compared to microscopy, as well as factors associated with discordant diagnostic results are also presented. P. falciparum infection prevalence was estimated at 7.0% (95% CI 4.9-9.0%) using microscopy. Using microscopy as the gold standard, the sensitivity of the HRP-2 RDT was 100% and specificity was 91.5%; positive predictive value was estimated to be 46.7% (95% CI 36.3-57.4%). RDT discordance, or HRP-2 false positivity, was highest among older children, those in the northern part of Luangwa District, and those with a reported history of antimalarial treatment. These data suggest microscopy should remain the gold standard for estimating malaria parasite point prevalence from household surveys for monitoring and evaluation purposes. © 2009 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Keating, Joseph A.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Miller, John M.
Zambia, Lusaka
Chainama Hills College Hospital
Bennett, Adam F.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Moonga, Hawela B.
Zambia, Lusaka
Zambian Ministry of Health
Eisele, Thomas P.
United States, New Orleans
Tulane University School of Public Health and Tropical Medicine
Statistics
Citations: 52
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1016/j.actatropica.2009.08.011
ISSN:
0001706X
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Zambia