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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies
PLoS Genetics, Volume 8, No. 4, Article e1002641, Year 2012
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Description
African Pygmy groups show a distinctive pattern of phenotypic variation, including short stature, which is thought to reflect past adaptation to a tropical environment. Here, we analyze Illumina 1M SNP array data in three Western Pygmy populations from Cameroon and three neighboring Bantu-speaking agricultural populations with whom they have admixed. We infer genome-wide ancestry, scan for signals of positive selection, and perform targeted genetic association with measured height variation. We identify multiple regions throughout the genome that may have played a role in adaptive evolution, many of which contain loci with roles in growth hormone, insulin, and insulin-like growth factor signaling pathways, as well as immunity and neuroendocrine signaling involved in reproduction and metabolism. The most striking results are found on chromosome 3, which harbors a cluster of selection and association signals between approximately 45 and 60 Mb. This region also includes the positional candidate genes DOCK3, which is known to be associated with height variation in Europeans, and CISH, a negative regulator of cytokine signaling known to inhibit growth hormone-stimulated STAT5 signaling. Finally, pathway analysis for genes near the strongest signals of association with height indicates enrichment for loci involved in insulin and insulin-like growth factor signaling. © 2012 Jarvis et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s001.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s002.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s003.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s004.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s005.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s006.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s007.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s008.eps
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s009.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s010.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s011.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s012.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s013.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s014.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s015.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s016.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s017.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s018.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s019.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s020.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC3343053/bin/pgen.1002641.s021.xlsx
Authors & Co-Authors
Jarvis, Joseph P.
United States, Philadelphia
University of Pennsylvania
Scheinfeldt, Laura
United States, Philadelphia
University of Pennsylvania
Soi, Sameer
United States, Philadelphia
University of Pennsylvania
Lambert, Charla
United States, Philadelphia
University of Pennsylvania
Omberg, Larsson
United States, Ithaca
Cornell University
Ferwerda, Bart
United States, Philadelphia
University of Pennsylvania
Froment, Alain
France, Paris
Museé de L'homme
Bodo, Jean Marie
Cameroon, Yaounde
Ministère de la Recherche Scientifique et de L’innovation Minresi
Beggs, William R.
United States, Philadelphia
University of Pennsylvania
Hoffman, Gabriel E.
United States, Ithaca
Cornell University
Mezey, Jason G.
United States, Ithaca
Cornell University
United States, New York
Weill Cornell Medicine
Tishkoff, Sarah A.
United States, Philadelphia
University of Pennsylvania
Statistics
Citations: 127
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pgen.1002641
e-ISSN:
15537404
Research Areas
Genetics And Genomics
Study Locations
Multi-countries
Cameroon