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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
International field testing of the reliability and validity of the EORTC QLQ-BM22 module to assess health-related quality of life in patients with bone metastases
Cancer, Volume 118, No. 5, Year 2012
Notification
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Description
Background: The objective of this international field study was to test the reliability, validity, and responsiveness of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-BM22 module to assess health-related quality of life (HRQOL) in patients with bone metastases. Methods: Patients undergoing a variety of bone metastases-specific treatments were accrued. The QLQ-BM22 was administered with the QLQ-C30 at baseline and at 1 follow-up time point internationally. A debriefing questionnaire was administered to determine patient acceptability and understanding. Results: Large-scale field testing of the QLQ-BM22 in addition to the QLQ-C30 took place in 7 countries: Brazil, Canada, Cyprus, Egypt, France, India, and Taiwan. A total of 400 patients participated. Multitrait scaling analyses confirmed 4 scales in the 22-item module. The scales were able to discriminate between clinically distinct patient groups, such as between those with a poor and those with a better performance status. The QLQ-BM22 was well received in all 7 countries, and the majority of patients did not recommend any significant changes from the module in its current form. Conclusions: The final QLQ-BM22 module contains 22 items and 4 scales assessing Painful Sites, Painful Characteristics, Functional Interference, and Psychosocial Aspects. Results confirmed the validity, reliability, cross-cultural applicability, and sensitivity of the 22-item EORTC QLQ-BM22. It is therefore recommended that the QLQ-BM22 be used in addition to the QLQ-C30 in clinical trials to assess HRQOL in patients with bone metastases. © 2011 American Cancer Society.
Authors & Co-Authors
Chow, Edwardedward L.W.
Canada, Toronto
University of Toronto
Nguyen, Janet
Canada, Toronto
University of Toronto
Zhang, Liying
Canada, Toronto
University of Toronto
Tseng, Lingming
Taiwan, Taipei
National Yang-ming University Taiwan
Hou, Mingfeng
Taiwan, Kaohsiung
Kaohsiung Medical University Chung-ho Memorial Hospital
Fairchild, Alysa M.
Canada, Edmonton
Cross Cancer Institute
Vassiliou, Vassilios P.
Cyprus, Nicosia
Bank of Cyprus Group Oncology Centre
Jesus-Garcia, Reynaldo
Brazil, Sao Paulo
Universidade Federal de São Paulo
Alm el-Din, Mohamed A.
Egypt, Tanta
Tanta University Hospitals
Kumar, Aswin
India, Thiruvananthapuram
Regional Cancer Centre India
Forges, Fabien
France, Saint-etienne
Université Jean Monnet Saint Etienne
France, Saint-priest-en-jarez
Saint-etienne University Hospital
Chie, Wei-Chu
Taiwan, Taipei
National Taiwan University
Bottomley, Andrew
Belgium, Brussels
European Organisation for Research and Treatment of Cancer
Statistics
Citations: 63
Authors: 13
Affiliations: 12
Identifiers
Doi:
10.1002/cncr.26410
ISSN:
0008543X
e-ISSN:
10970142
Research Areas
Cancer
Disability
Health System And Policy
Study Design
Cohort Study
Study Locations
Egypt