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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Genomic characterization of human rotavirus G10 strains from the African Rotavirus Network: Relationship to animal rotaviruses
Infection, Genetics and Evolution, Volume 11, No. 1, Year 2011
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Description
Global rotavirus surveillance has led to the detection of many unusual human rotavirus (HRV) genotypes. The aim of this study was to elucidate the genetic and evolutionary relationships of short fragments of all 11 gene segments of G10 HRV strains identified in West Africa through the African Rotavirus Network (ARN) system. During 1998-2004 surveillance within the ARN, we identified 5 G10 P[8] HRV strains. Fragments of all 11 gene segments of these G10 strains were sequenced. Phylogenetic and sequence analyses of each gene segment revealed high nucleotide similarities amongst the ARN strains (97-100%) except in the case of the VP1(85-96%) and NSP2 genes (87.8-99.7%) where some strains were divergent. All genes of the ARN strains were classified as Wa-like (genotype 1) with the exception of their VP7 gene of all strains (genotype G10) and the VP6 gene of a single strain, 6755/2002/ARN (DS-1 like, genotype 2). While classified as Wa-like, the NSP2 genes of four of the ARN strains occupied a distinct sub-lineage related to simian strain Tuch, while the NSP2 of strain 6755/2002/ARN and NSP5 genes of all strains were closely related to the cognate genes of both human and animal strains belonging to the Wa-like genogroup. Although these findings help to elucidate the evolution of ARN G10 strains, additional sequence studies of cognate animal rotavirus genes are needed to determine irrefutably the specific origin of those genes relative to both human and animal rotavirus strains. © 2010.
Authors & Co-Authors
Esona, Mathew Dioh
United States, Atlanta
Centers for Disease Control and Prevention
Bányai, Krisztián
United States, Atlanta
Centers for Disease Control and Prevention
Hungary, Budapest
Magyar Tudomanyos Akademia
Foytich, Kimberly R.
United States, Atlanta
Centers for Disease Control and Prevention
Freeman, Molly M.
United States, Atlanta
Centers for Disease Control and Prevention
Mijatovic-Rustempasic, Slavica
United States, Atlanta
Centers for Disease Control and Prevention
Hull, Jennifer J.A.
United States, Atlanta
Centers for Disease Control and Prevention
Kerin, Tara K.
United States, Atlanta
Centers for Disease Control and Prevention
Steele, Andrew Duncan
United States, Seattle
Path Seattle
Armah, George Enyimah
Unknown Affiliation
Geyer, Annelise
South Africa, Sovenga
University of Limpopo
Page, Nicola A.
South Africa, Sandringham
National Institute for Communicable Disease
Agbaya, V. A.
France, Abidjan
Institut Pasteur de Cote-d Ivoire/dve
Forbi, Joseph C.
Nigeria, Maiduguri
Virology Laboratory
Aminu, Maryam Maryam
Nigeria, Zaria
Ahmadu Bello University
Gautam, Rashi
United States, Atlanta
Centers for Disease Control and Prevention
Seheri, Luyanda Mapaseka
South Africa, Sovenga
University of Limpopo
Nyangao, James W.O.
Kenya, Nairobi
Kenya Industrial Research and Development Institute
Glass, Roger I.M.
United States, Bethesda
National Institutes of Health Nih
Bowen, Michael D.
United States, Atlanta
Centers for Disease Control and Prevention
Gentsch, Jon R.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 35
Authors: 20
Affiliations: 11
Identifiers
Doi:
10.1016/j.meegid.2010.09.010
ISSN:
15671348
Research Areas
Genetics And Genomics
Study Locations
Multi-countries