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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Clinical and Virologie Efficacy of Herpes Simplex Virus Type 2 Suppression by Acyclovir in a Multicontinent Clinical Trial
Journal of Infectious Diseases, Volume 201, No. 8, Year 2010
Notification
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Description
Acyclovir suppressive therapy (400 mg twice daily) reduces herpes simplex virus (HSV) type 2-associated genital ulcer disease and lesionai HSV shedding. In an international trial of acyclovir for suppression of HSV type 2 to prevent human immunodeficiency virus (HIV) acquisition (HIV Prevention Trials Network 039), acyclovir had a smaller effect on the frequency of genital ulcer disease as well as a smaller effect on the frequency and quantity of lesional HSV DNA in Af-rican women and Peruvian men, compared with its effects in men in the United States. The observed regional varia-tion in the clinical and virologic efficacy of acyclovir for HSV suppression warrants further evaluation of determinants of responses to acyclovir. (ClinicalTrials.gov identifier: NCT00076232.) © 2010 by the Infectious Diseases Society of America, All rights reserved.
Authors & Co-Authors
Fuchs, Jonathan D.
United States, San Francisco
San Francisco Department of Public Health
United States, San Francisco
Ucsf School of Medicine
Celum, Connie L.
Unknown Affiliation
Wang, Jing
United States, Seattle
Fred Hutchinson Cancer Research Center
Hughes, James P.
United States, Seattle
University of Washington
Sánchez, Jorge L.
United States, Lima
Asociación Civil Salud y Educación
Cowan, Frances Mary
United Kingdom, London
Ucl Medical School
Reid, Stewart E.
United States, Birmingham
The University of Alabama at Birmingham
Zambia, Lusaka
Centre for Infectious Disease Research
Delany-Moretlwe, Sinead
South Africa, Johannesburg
University of the Witwatersrand
Corey, Lawrence
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Wald, Anna
United States, Seattle
University of Washington
United States, Seattle
Fred Hutchinson Cancer Research Center
Statistics
Citations: 24
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1086/651381
ISSN:
00221899
Research Areas
Genetics And Genomics
Infectious Diseases
Sexual And Reproductive Health
Participants Gender
Male
Female