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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Platelet survival in patients with beta‐thalassemia
American Journal of Hematology, Volume 32, No. 2, Year 1989
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Description
Thromboembolic events associated with significant morbidity and mortality have been observed in patients with beta‐thalassemia major (TM). These include arterial as well as venous thrombosis and the development of early arteriosclerosis. To elucidate the possibility that TM patients may develop a hypercoagulable state we carried out a study of platelet kinetics on ten patients with TM and four patients with thalassemia intermedia (TI). Autologous platelets were labeled with indium‐111‐oxine, and the platelet lifespan (PLS) was determined. A significant shortening of PLS was observed in 13 out of 14 patients examined. The mean PLS (±1 SD) in ten patients (8 TM, 2 TI) who underwent splenectomy was 107 ± 36 hr (control splenectomized 248 + 51 hr) (P < .001) and in four nonsplenectomized patients (2 TM, 2 TI) was 102 ± 64 hr (control 224 + 23 hr) (P < .01). The short PLS in addition to reported findings of increased circulating platelet aggregates and the decreased response of TM platelets to aggregating agents suggests in vivo platelet activation in thalassemic patients. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company
Authors & Co-Authors
Eldor, Amiram
Israel, Jerusalem
Departments of Hematology
Krausz, Yodphat
Israel, Jerusalem
Hadassah University Medical Centre
Atlan, Henri
Israel, Jerusalem
Hadassah University Medical Centre
Snyder, D.
Israel, Jerusalem
Hadassah University Medical Centre
Goldfarb, Ada W.
Israel, Jerusalem
Departments of Hematology
Hy‐Am, E.
Israel, Jerusalem
Hadassah University Medical Centre
Rachmilewitz, Eliezer A.
Israel, Jerusalem
Departments of Hematology
Kotzè, Harry F.
South Africa, Bloemfontein
University of the Free State
Heyns, Anthon Du P.
South Africa, Bloemfontein
University of the Free State
Statistics
Citations: 52
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1002/ajh.2830320204
ISSN:
03618609
e-ISSN:
10968652