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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
Rheumatology (United Kingdom), Volume 59, No. 8, Year 2020
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Description
Objectives: Smoking is a major risk factor for the development of both cardiovascular disease (CVD) and RA and may cause attenuated responses to anti-rheumatic treatments. Our aim was to compare disease activity, CVD risk factors and CVD event rates across smoking status in RA patients. Methods: Disease characteristics, CVD risk factors and relevant medications were recorded in RA patients without prior CVD from 10 countries (Norway, UK, Netherlands, USA, Sweden, Greece, South Africa, Spain, Canada and Mexico). Information on CVD events was collected. Adjusted analysis of variance, logistic regression and Cox models were applied to compare RA disease activity (DAS28), CVD risk factors and event rates across categories of smoking status. Results: Of the 3311 RA patients (1012 former, 887 current and 1412 never smokers), 235 experienced CVD events during a median follow-up of 3.5 years (interquartile range 2.5-6.1). At enrolment, current smokers were more likely to have moderate or high disease activity compared with former and never smokers (P < 0.001 for both). There was a gradient of worsening CVD risk factor profiles (lipoproteins and blood pressure) from never to former to current smokers. Furthermore, former and never smokers had significantly lower CVD event rates compared with current smokers [hazard ratio 0.70 (95% CI 0.51, 0.95), P = 0.02 and 0.48 (0.34, 0.69), P < 0.001, respectively]. The CVD event rates for former and never smokers were comparable. Conclusion: Smoking cessation in patients with RA was associated with lower disease activity and improved lipid profiles and was a predictor of reduced rates of CVD events. © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology.
Authors & Co-Authors
Ikdahl, Eirik
Norway, Oslo
Diakonhjemmet Sykehus
Rollefstad, Silvia
Norway, Oslo
Diakonhjemmet Sykehus
Kitas, George D.
United Kingdom, Birmingham
University of Birmingham
United Kingdom, Dudley
The Dudley Group Nhs Foundation Trust
van Riel, Piet L.C.M.
Netherlands, Nijmegen
Radboud Universiteit
Gabriel, Sherine E.
United States, Rochester
Mayo Clinic
Kvien, Tore Kristian
Norway, Oslo
Diakonhjemmet Sykehus
Norway, Oslo
Universitetet I Oslo
Douglas, Karen May Jane
United Kingdom, Dudley
The Dudley Group Nhs Foundation Trust
Wållberg-Jonsson, Solveig
Sweden, Umea
Umeå Universitet
Rantapåå-Dahlqvist, Solbritt
Sweden, Umea
Umeå Universitet
Karpouzas, George Athanasios
United States, Torrance
Harbor-ucla Medical Center
Dessein, Patrick Hector M.C.
Belgium, Brussels
Vrije Universiteit Brussel
Belgium, Jette
Universitair Ziekenhuis Brussel
Tsang, Linda
Belgium, Jette
Universitair Ziekenhuis Brussel
El-Gabalawy, Hani S.
Canada, Winnipeg
University of Manitoba
Hitchon, Carol Ann
Canada, Winnipeg
University of Manitoba
Pascual-Ramos, Virginia
Mexico, Tlalpan
Instituto Nacional de la Nutrición Salvador Zubiran
SFIKAKIS, P. Paul
Greece, Athens
National and Kapodistrian University of Athens
González-Gay, Miguel Ángel
Spain, Santander
Universidad de Cantabria
Crowson, Cynthia S.
United States, Rochester
Mayo Clinic
Semb, Anne Grete P.
Norway, Oslo
Diakonhjemmet Sykehus
Statistics
Citations: 27
Authors: 19
Affiliations: 16
Identifiers
Doi:
10.1093/rheumatology/kez557
ISSN:
14620324
Research Areas
Environmental
Noncommunicable Diseases
Study Design
Cohort Study
Study Locations
South Africa